PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:50-1:100 |
| Pretreatment | No Pretreatment Required |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Albumin Information for Pathologists
Summary:
Most common serum protein. 65K protein produced by ALB gene on #4, by liver (Wikipedia). 50% of total plasma protein content; usual serum concentration of 40 g/L. Binds to water, bilirubin, calcium, fatty acids, hormones (acts as carrier protein), potassium, sodium, and various drugs. Main function of serum albumin is to regulate blood colloidal osmotic pressure.
Notable Clinical Features:
Laboratory:. For serum albumin measure, most instrument systems do NOT have satisfactory total-error performance (Arch Pathol Lab Med 2013;137:912). Serum albumin may be a low cost diagnostic marker for tuberculosis in HIV+ patients eligible for antiretroviral therapy (Bioimpacts 2013;3:123). In type 2 diabetes patients with stable angina and chronic total coronary occlusion, increased serum glycated albumin levels are associated with impaired coronary collateral growth (Cardiovasc Diabetol 2013;12:165). Deficiency causes familial dysalbuminemic hyperthyroxinemia (MIM:103600).
| Albumin General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 69.4 kDa | |
| Chromosomal Location | |
| q13.3 [chr: 4] [chr_start: 73397114] [chr_end: 73421482] [strand: 1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ALB |
| Entrez Gene ID | 213 |
| RefSeq Protein Accession(s) | NP_000468 |
| RefSeq mRNA Accession(s) | NM_000477; |
| RefSeq Genomic Accession(s) | NG_009291; NC_000004 |
| UniProt ID(s) | P02768 |
| PharmGKB ID(s) | PA24690 |
| KEGG Gene ID(s) | hsa:213 |
| Associated Diseases (KEGG IDs) | Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269|PubMed:7852505, ECO:0000269|PubMed:8048949, ECO:0000269|PubMed:9329347, ECO:0000269|PubMed:9589637}. The disease is caused by mutations affecting the gene represented in this entry.; Analbuminemia (ANALBA) [MIM:616000]: A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. {ECO:0000269|PubMed:8134387}. The disease is caused by mutations affecting the gene represented in this entry. |
| General Description of Albumin . | |
| This antibody reacts with human albumin. This antibody is essentially free of other rabbit serum proteins. Specificity is determined by Ouchterlony double diffusion (ODD) and immunoelectrophoresis (IEP) versus human serum and human albumin. | |
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