Anti-ALK Antibody Clone ALK/1503

Observed Antibody Staining Data By Tissue Type:

Variations in ALK antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in neuronal cells in the cerebral cortex and hippocampus and Purkinje cells in the cerebellum. More moderate antibody staining intensity was present in neuronal cells in the cerebral cortex and hippocampus and Purkinje cells in the cerebellum. Low, but measureable presence of ALK could be seen in cells in the endometrial stroma in endometrium, cells in the molecular layer in cerebellum, decidual cells in the placenta, endothelial cells in the cerebral cortex, epidermal cells in the skin, fibroblasts in mesenchymal tissue, germinal center cells in the lymph node, glandular cells in the adrenal gland, colon, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, rectum, seminal vesicle and thyroid gland, hematopoietic cells in the bone marrow, Langerhans in skin, Leydig cells in the testis, macrophages in lung, myocytes in heart muscle and skeletal muscle, non-germinal center cells in the lymph node, ovarian stroma cells in the ovary, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, oral mucosa and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect ALK in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.