PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | No Pretreatment Required |
| Incubation Parameters | 30 min at RoomTemperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
alpha-1-Antichymotrypsin Information for Pathologists
Summary:
Also called ?1-ACT. Acute phase protein / plasma protease inhibitor, mainly produced by liver in response to cytokines such as oncostatin M. May limit tissue damage produced by excessive inflammation associated proteolysis. Also localizes to nuclei of hepatic cells to control chromatin condensation and proliferation (Gastroenterology 2013;144:818). Homologous to alpha-1-antitrypsin.
Notable Clinical Features:
Heart: has role in pathophysiology of heart failure (Circ Heart Fail 2013;6:853). Kidney: part of plasma molecular profile associated with acute cellular renal allograft rejection (Transplantation 2011;92:388). Skin: has role in skin repair (J Biol Chem 2011;286:28889). Umbilical cord: may help differentiate between stillborns and liveborns (Pathol Res Pract 2009;205:534). Uses by pathologists
Common Uses By Pathologists:
Marker for acinic / acinar cell carcinoma in breast (Case Rep Oncol Med 2013;2013:372947), pancreas, salivary gland.
| alpha-1-Antichymotrypsin General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 47.7 kDa | |
| Chromosomal Location | |
| q32.13 [chr: 14] [chr_start: 94612377] [chr_end: 94624055] [strand: 1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SERPINA3 |
| Entrez Gene ID | 12 |
| RefSeq Protein Accession(s) | NP_001076 |
| RefSeq mRNA Accession(s) | ; NM_001085 |
| RefSeq Genomic Accession(s) | NG_012879; NC_000014 |
| UniProt ID(s) | P01011 |
| PharmGKB ID(s) | PA35020 |
| KEGG Gene ID(s) | hsa:12 |
| General Description of alpha-1-Antichymotrypsin . | |
| The antibody is specific against human alpha-1-antichymotrypsin. This antibody stains monocytes and macrophages in human tissues and does not stain any other cell type. | |
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