PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:50-1:150 |
| Pretreatment | No Pretreatment Required |
| Incubation Parameters | 30 min at RoomTemperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
alpha-1-Fetoprotein Information for Pathologists
Summary:
Major plasma protein of early fetus; present in fetal gut, liver and yolk sac (Wikipedia). Serum levels may be elevated if severe hypothyroidism (J Pediatr Endocrinol Metab 2012;25:761). Uses by pathologists Serum marker:. Elevated in maternal serum or amniotic fluid ( > 2.5 multiples of median at a specified gestational age) if fetal developmental anomalies.
Common Uses By Pathologists:
Serum marker:. Elevated in maternal serum or amniotic fluid ( > 2.5 multiples of median at a specified gestational age) if fetal developmental anomalies. Serum tumor marker elevated in patients with hepatoblastoma (eMedicine), hepatocellular carcinoma, hepatoid adenocarcinoma, testicular cancer (other than pure seminoma) and yolk sac tumor, but not in intrahepatic cholangiocarcinoma (Am Surg 2010;76:1210). Preoperative levels are prognostic for hepatocellular carcinoma (World J Surg Oncol 2013;11:212). Immunostain:.
| alpha-1-Fetoprotein General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 68.7 kDa | |
| Chromosomal Location | |
| q13.3 [chr: 4] [chr_start: 73431138] [chr_end: 73456174] [strand: 1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | AFP |
| Entrez Gene ID | 174 |
| RefSeq Protein Accession(s) | NP_001125 |
| RefSeq mRNA Accession(s) | ; NM_001134; NM_001354717 |
| RefSeq Genomic Accession(s) | NC_000004; NG_023028 |
| UniProt ID(s) | P02771 |
| PharmGKB ID(s) | PA24614 |
| KEGG Gene ID(s) | hsa:174 |
| Associated Diseases (KEGG IDs) | Alpha-fetoprotein deficiency (AFPD) [MIM:615969]: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development. {ECO:0000269|PubMed:15280901, ECO:0000269|PubMed:18854864}. The disease is caused by mutations affecting the gene represented in this entry.; Alpha-fetoprotein, hereditary persistence (HPAFP) [MIM:615970]: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life. {ECO:0000269|PubMed:7684942}. The disease is caused by mutations affecting the gene represented in this entry. |
| General Description of alpha-1-Fetoprotein . | |
| This antibody reacts with alpha-1-fetoprotein. A positive staining in the hepatocytes of fetal tissue was observed. This antibody does not react with any other cell or tissue types. | |
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