alpha Fetoprotein [C3] Antibody (cGMP).

$ 135.00 – $ 345.00

SKU: QIVD217
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG2a

PDF Datasheet

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.

Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.

Application Notes

Specification	Recommendation
Recommended Dilution (Conc)	1:25-1:50
Pretreatment	No Pretreatment Required
Incubation Parameters	30 min at RoomTemperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal

Anti-alpha Fetoprotein Antibody Clone: C3

Host and Isotype: Mouse IgG2a

Recommended Positive Control Sample: Fetal liver

Cellular Localization of Antibody C3 Staining: Cytoplasmic

Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN₃

Antibody Concentration: Lot specific. Plese contact tech support for data.

Immunogen: BALB/C mice were injected with purified human alpha-fetoprotein.

Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

alpha Fetoprotein Information for Pathologists

Summary:

Major plasma protein of early fetus; present in fetal gut, liver and yolk sac (Wikipedia). Serum levels may be elevated if severe hypothyroidism (J Pediatr Endocrinol Metab 2012;25:761). Uses by pathologists Serum marker:. Elevated in maternal serum or amniotic fluid ( > 2.5 multiples of median at a specified gestational age) if fetal developmental anomalies.

Common Uses By Pathologists:

Serum marker:. Elevated in maternal serum or amniotic fluid ( > 2.5 multiples of median at a specified gestational age) if fetal developmental anomalies. Serum tumor marker elevated in patients with hepatoblastoma (eMedicine), hepatocellular carcinoma, hepatoid adenocarcinoma, testicular cancer (other than pure seminoma) and yolk sac tumor, but not in intrahepatic cholangiocarcinoma (Am Surg 2010;76:1210). Preoperative levels are prognostic for hepatocellular carcinoma (World J Surg Oncol 2013;11:212). Immunostain:.

alpha Fetoprotein General Information
Alternate Names

Molecular Weight
68.7 kDa
Chromosomal Location
q13.3 [chr: 4] [chr_start: 73431138] [chr_end: 73456174] [strand: 1]
Curated Database and Bioinformatic Data
Gene Symbol	AFP
Entrez Gene ID	174
RefSeq Protein Accession(s)	NP_001125
RefSeq mRNA Accession(s)	; NM_001134; NM_001354717
RefSeq Genomic Accession(s)	NC_000004; NG_023028
UniProt ID(s)	P02771
PharmGKB ID(s)	PA24614
KEGG Gene ID(s)	hsa:174
Associated Diseases (KEGG IDs)	Alpha-fetoprotein deficiency (AFPD) [MIM:615969]: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development. {ECO:0000269\|PubMed:15280901, ECO:0000269\|PubMed:18854864}. The disease is caused by mutations affecting the gene represented in this entry.; Alpha-fetoprotein, hereditary persistence (HPAFP) [MIM:615970]: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life. {ECO:0000269\|PubMed:7684942}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of alpha Fetoprotein .
alpha-fetoprotein (AFP) is a single chain glycoprotein of 70 kDa that is normally expressed in the fetal liver, gastrointestinal tract and yolk sac. This antibody recognizes an epitope of alpha-fetoprotein present in human and several other species.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

Size	0.1 ml, 6 ml, 0.5 ml, 1 ml
Tag	Unconjugated
Buffer and Stabilizer	PBS with 1% BSA and 0.05% NaN3
Product Type	Antibody
Host	Mouse
Isotype	IgG2a
Applications	IHC
Species	Human
Format	Concentrate, Predilute

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