PDF Datasheet

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.

Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.

Application Notes

Specification	Recommendation
Recommended Dilution (Conc)	1:100-1:200
Pretreatment	Citrate Buffer pH 6.0
Incubation Parameters	30 min at RoomTemperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal

Anti-Androgen Receptor Antibody Clone: AR 441

Host and Isotype: Mouse IgG1

Recommended Positive Control Sample: Prostate carcinoma

Cellular Localization of Antibody AR 441 Staining: Nuclear

Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN₃

Antibody Concentration: Lot specific. Plese contact tech support for data.

Immunogen: BALB/C mice were injected with a synthetic peptide corresponding to the human androgen receptor.

Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

Androgen Receptor Information for Pathologists

Androgen Receptor General Information
Alternate Names

Molecular Weight
99.2 kDa
Chromosomal Location
q12 [chr: X] [chr_start: 67544032] [chr_end: 67730619] [strand: 1]
Curated Database and Bioinformatic Data
Gene Symbol	AR
Entrez Gene ID	367
RefSeq Protein Accession(s)	NP_001334993; NP_001334990; NP_001011645; NP_001334992; NP_000035
RefSeq mRNA Accession(s)	NM_001348063; NM_001348064; NM_001011645; NM_001348061; NM_000044
RefSeq Genomic Accession(s)	NG_009014; NC_000023
UniProt ID(s)	P10275
PharmGKB ID(s)	PA57
KEGG Gene ID(s)	hsa:367
Associated Diseases (KEGG IDs)	Androgen insensitivity syndrome (AIS) [MIM:300068]: An X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype. {ECO:0000269\|PubMed:10022458, ECO:0000269\|PubMed:10221692, ECO:0000269\|PubMed:10221770, ECO:0000269\|PubMed:10404311, ECO:0000269\|PubMed:10458483, ECO:0000269\|PubMed:10571951, ECO:0000269\|PubMed:10590024, ECO:0000269\|PubMed:10690872, ECO:0000269\|PubMed:11587068, ECO:0000269\|PubMed:11744994, ECO:0000269\|PubMed:1307250, ECO:0000269\|PubMed:1316540, ECO:0000269\|PubMed:1426313, ECO:0000269\|PubMed:1430233, ECO:0000269\|PubMed:1464650, ECO:0000269\|PubMed:14756668, ECO:0000269\|PubMed:1480178, ECO:0000269\|PubMed:1487249, ECO:0000269\|PubMed:1569163, ECO:0000269\|PubMed:1609793, ECO:0000269\|PubMed:16129672, ECO:0000269\|PubMed:16595706, ECO:0000269\|PubMed:1775137, ECO:0000269\|PubMed:1999491, ECO:0000269\|PubMed:2082179, ECO:0000269\|PubMed:2594783, ECO:0000269\|PubMed:7537149, ECO:0000269\|PubMed:7581399, ECO:0000269\|PubMed:7633398, ECO:0000269\|PubMed:7641413, ECO:0000269\|PubMed:7671849, ECO:0000269\|PubMed:7929841, ECO:0000269\|PubMed:7962294, ECO:0000269\|PubMed:7970939, ECO:0000269\|PubMed:7981687, ECO:0000269\|PubMed:7981689, ECO:0000269\|PubMed:7993455, ECO:0000269\|PubMed:8040309, ECO:0000269\|PubMed:8096390, ECO:0000269\|PubMed:8103398, ECO:0000269\|PubMed:8162033, ECO:0000269\|PubMed:8224266, ECO:0000269\|PubMed:8281140, ECO:0000269\|PubMed:8325950, ECO:0000269\|PubMed:8339746, ECO:0000269\|PubMed:8413310, ECO:0000269\|PubMed:8446106, ECO:0000269\|PubMed:8626869, ECO:0000269\|PubMed:8647313, ECO:0000269\|PubMed:8683794, ECO:0000269\|PubMed:8723113, ECO:0000269\|PubMed:8768864, ECO:0000269\|PubMed:8809734, ECO:0000269\|PubMed:8830623, ECO:0000269\|PubMed:8918984, ECO:0000269\|PubMed:8990010, ECO:0000269\|PubMed:9001799, ECO:0000269\|PubMed:9007482, ECO:0000269\|PubMed:9039340, ECO:0000269\|PubMed:9106550, ECO:0000269\|PubMed:9160185, ECO:0000269\|PubMed:9252933, ECO:0000269\|PubMed:9255042, ECO:0000269\|PubMed:9302173, ECO:0000269\|PubMed:9328206, ECO:0000269\|PubMed:9544375, ECO:0000269\|PubMed:9554754, ECO:0000269\|PubMed:9610419, ECO:0000269\|PubMed:9627582, ECO:0000269\|PubMed:9698822, ECO:0000269\|PubMed:9851768, ECO:0000269\|PubMed:9856504, ECO:0000269\|Ref.113, ECO:0000269\|Ref.179}. The disease is caused by mutations affecting the gene represented in this entry.; Spinal and bulbar muscular atrophy X-linked 1 (SMAX1) [MIM:313200]: An X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. {ECO:0000269\|PubMed:15851746}. The disease is caused by mutations affecting the gene represented in this entry. Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.; Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. {ECO:0000269\|PubMed:10363963, ECO:0000269\|PubMed:10569618, ECO:0000269\|PubMed:1562539, ECO:0000269\|PubMed:16129672, ECO:0000269\|PubMed:17311914, ECO:0000269\|PubMed:2260966, ECO:0000269\|PubMed:25091737, ECO:0000269\|PubMed:8187068, ECO:0000269\|PubMed:8274409, ECO:0000269\|PubMed:8827083}.; Androgen insensitivity, partial (PAIS) [MIM:312300]: A disorder that is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations. {ECO:0000269\|PubMed:10022458, ECO:0000269\|PubMed:10221692, ECO:0000269\|PubMed:10470409, ECO:0000269\|PubMed:10502786, ECO:0000269\|PubMed:10543676, ECO:0000269\|PubMed:11587068, ECO:0000269\|PubMed:1303262, ECO:0000269\|PubMed:1307250, ECO:0000269\|PubMed:1316540, ECO:0000269\|PubMed:1424203, ECO:0000269\|PubMed:1430233, ECO:0000269\|PubMed:14756668, ECO:0000269\|PubMed:2010552, ECO:0000269\|PubMed:7581399, ECO:0000269\|PubMed:7649358, ECO:0000269\|PubMed:7671849, ECO:0000269\|PubMed:7909256, ECO:0000269\|PubMed:7910529, ECO:0000269\|PubMed:7929841, ECO:0000269\|PubMed:7970939, ECO:0000269\|PubMed:7981687, ECO:0000269\|PubMed:8033918, ECO:0000269\|PubMed:8097257, ECO:0000269\|PubMed:8126121, ECO:0000269\|PubMed:8205256, ECO:0000269\|PubMed:8281139, ECO:0000269\|PubMed:8325932, ECO:0000269\|PubMed:8325950, ECO:0000269\|PubMed:8446106, ECO:0000269\|PubMed:8550758, ECO:0000269\|PubMed:8809734, ECO:0000269\|PubMed:8823308, ECO:0000269\|PubMed:8824883, ECO:0000269\|PubMed:9039340, ECO:0000269\|PubMed:9196614, ECO:0000269\|PubMed:9302173, ECO:0000269\|PubMed:9329414, ECO:0000269\|PubMed:9543136, ECO:0000269\|PubMed:9607727, ECO:0000269\|PubMed:9768671, ECO:0000269\|PubMed:9856504, ECO:0000269\|Ref.121}. The disease is caused by mutations affecting the gene represented in this entry.; Hypospadias 1, X-linked (HYSP1) [MIM:300633]: A common malformation in which the urethra opens on the ventral side of the penis, due to developmental arrest of urethral fusion. The opening can be located glandular, penile, or even more posterior in the scrotum or perineum. Hypospadias is a feature of several syndromic disorders, including the androgen insensitivity syndrome and Opitz syndrome. {ECO:0000269\|PubMed:8097257}. The disease is caused by mutations affecting the gene represented in this entry.
General Description of Androgen Receptor .
This antibody is specific to a protein of 110 kDa, identified as androgen receptor. This antibody reacts with full length AR and also with the newly described A form of the receptor. This antibody does not cross-react with estrogen, progesterone or glucocorticoid receptors.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

Size	0.1 ml, 6 ml, 0.5 ml, 1 ml
Tag	Unconjugated
Buffer and Stabilizer	PBS with 1% BSA and 0.05% NaN3
Product Type	Antibody
Host	Mouse
Isotype	IgG1
Applications	IHC
Species	Human
Format	Concentrate, Predilute

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Androgen Receptor [AR 441] Antibody (cGMP).

Antibody (Suitable for clinical applications)

Androgen Receptor Information for Pathologists

Limitations and Warranty

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