PDF DatasheetMouse Anti-Anti-CD154 / TNFSF5 Antibody Product Attributes
Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-Anti-CD154 / TNFSF5 Antibody Clone: MR1
Clone MR1 Host and Isotype: Armenian Hamster IgG
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
Antibody Concentration: 0.5 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.
Anti-CD154 / TNFSF5 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD40L / CD154 / TNFSF5 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD40L / CD154 / TNFSF5 could be seen inhematopoietic cells in the bone marrow. We were unable to detect CD40L / CD154 / TNFSF5 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| Anti-CD154 / TNFSF5 General Information | |
|---|---|
| Alternate Names | |
| CD4L, CD154, TNFSF5, CD154, IGM, Ly-62, TRAP, Tnlg8b, HIGM1, CD4-L, Cd4l, Ly62, T-BAM, IMD3, Tnfsf5, gp39 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Cd40lg |
| Entrez Gene ID | 21947 |
| Ensemble Gene ID | ENSMUSG00000031132 |
| RefSeq Protein Accession(s) | NP_035746 |
| RefSeq mRNA Accession(s) | NM_011616 |
| RefSeq Genomic Accession(s) | NC_000086 |
| UniProt ID(s) | Q0VEI3, P27548 |
| UniGene ID(s) | Q0VEI3, P27548 |
| Cosmic ID(s) | Cd40lg |
| KEGG Gene ID(s) | mmu:21947 |
| General Description of Anti-CD154 / TNFSF5. | |
| The MR1 antibody is specific for mouse CD154, a 39 kD glycoprotein that is primarily expressed on activated T cells. CD154 (CD40 ligand, gp39) binds to CD40 expressed on antigen presenting cells and mediates important costimulatory functions between these cells. Signals generated via cognate interactions between CD154-CD40 on activated T and B cells are required for T-dependent B cell responses. The MR1 antibody is reported to block interaction of CD154 with CD40. | |
Selected References
Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. 1992. Proc Natl Acad Sci U S A. 89(14):6550-6554.Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ. 1994. J Exp Med. 180(1):157-163.Laman JD, Claassen E, Noelle RJ. 1996. Crit Rev Immunol. 16(1):59-108.Grewal IS, Flavell RA. 1998. Annu Rev Immunol. 16:111-35.
Limitations and Warranty
enQuire Bio’s Mouse Anti-CD154 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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