PDF DatasheetMouse Anti-Anti-CD314 Antibody Product Attributes
Species: Mouse
Tested Applications: Flow Cytometry.
Application Notes: See Product Datasheet for Recommended Dilution Range. Requires Experimental Optimization
Clonality: Monoclonal Antibody
Anti-Anti-CD314 Antibody Clone: CX5
Clone CX5 Host and Isotype: Rat IgG1 kappa
Buffer and Stabilizer: 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
Antibody Concentration: 0.5 mg/mL
Storage Conditions: 2-8C protected from light. Stable for 12 Months. Do Not Freeze.
Anti-CD314 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-KLRK1 antibody staining is expected to be primarily localized to the plasma membrane.
| Anti-CD314 General Information | |
|---|---|
| Alternate Names | |
| NKG2D, CD314, KLR, NKG2-D, NKG2D, D12S2489E, CD314 | |
| Curated Database and Bioinformatic Data | |
| Entrez Gene ID | 27007 |
| Ensemble Gene ID | ENSMUSG00000030149 |
| RefSeq Protein Accession(s) | NP_001272947, NP_149069, NP_001076791, XP_011239671 |
| RefSeq mRNA Accession(s) | NM_001286018, NM_033078, XM_011241369, NM_001083322 |
| RefSeq Genomic Accession(s) | NC_000072 |
| UniProt ID(s) | Q4FJM0, Q3TCW7, O54709 |
| UniGene ID(s) | Q4FJM0, Q3TCW7, O54709 |
| Cosmic ID(s) | Klrk1 |
| KEGG Gene ID(s) | mmu:27007 |
| General Description of Anti-CD314. | |
| The CX5 antibody is specific for mouse NKG2D (CD314, KLRK1), a lectin-like type II transmembrane receptor protein. NKG2D functions as an activating receptor on NK cells and a co-stimulatory receptor on cytotoxic T cells, in both cases associating with the DAP10 adaptor protein. It is not expressed on resting T cells or unstimulated macrophages. NKG2D binds to its ligands, often expressed on atypical cells, including MULT1, H60 and five RAE1 variants. The CX5 antibody is reported to block binding of NKG2D to its ligands. Please choose the appropriate format for each application. | |
Selected References
Cerwenka A, Bakker AB, McClanahan T, Wagner J, Wu J, Phillips JH and Lanier LL. 2000. Immunity. 12(6): 721-727. Carayannopoulos LN, Naidenko OV, Fremont DH and Yokoyama WM. 2002. J Immunol. 169(8): 4079-4083.Hamerman JA, Ogasawara K and Lanier LL. 2004. J Immunol. 172(4): 2001-2005. (Flow cytometry)Ogawawara K, Mamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA and Lanier LL. 2003. Immunity. 18: 41-51. (in vivo blocking)Andre MC, Siqurdardottir D, Kuttruff S, Pommerl B, Handgretinger R, Rammensee HG and Steinle A. 2012. Int J Cancer. 131(7): 1601-1610. (Flow cytometry)
Limitations and Warranty
enQuire Bio’s Mouse Anti-CD314 Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
There are no reviews yet.