PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
c-myc Information for Pathologists
Summary:
Proto-oncogene at 8q24.1 produces short lived nuclear phosphoprotein. Overexpressed by t(8;14)(q24;q32.3), t(8;22);(q24;11) and t(2;8);(p11-12;q24), which translocate c-myc gene next to immunoglobulin genes in Burkitts lymphoma. Gene expressed in virtually all eukaryotic cells; expression usually tightly controlled. Immediate early growth response gene; rapidly induced when quiescent cells receive a signal to divide; required for cells to enter S phase.
| c-myc General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 48.8 kDa | |
| Chromosomal Location | |
| q24.21 [chr: 8] [chr_start: 127735434] [chr_end: 127742950] [strand: 1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MYC |
| Entrez Gene ID | 4609 |
| RefSeq Protein Accession(s) | NP_002458 |
| RefSeq mRNA Accession(s) | ; NM_001354870; NM_002467 |
| RefSeq Genomic Accession(s) | NC_000008; NG_007161 |
| UniProt ID(s) | P01106 |
| PharmGKB ID(s) | PA31353 |
| KEGG Gene ID(s) | hsa:4609 |
| Associated Diseases (KEGG IDs) | A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. {ECO:0000269|PubMed:2069907}.; Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269|PubMed:2166998, ECO:0000269|PubMed:8220424}. The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. |
| General Description of c-myc . | |
| This antibody recognizes an epitope located in the amino acid residue 410-419 of human oncogene product c-myc. This antibody reacts with both components of the p62 and p64 c-myc. | |
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