PDF DatasheetHuman Anti-C-Reactive Protein / CRP Antibody Product Attributes
C-Reactive Protein / CRP Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in C-Reactive Protein / CRP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hepatocytes in liver. More moderate antibody staining intensity was present in hepatocytes in liver. Low, but measureable presence of C-Reactive Protein / CRP could be seen infibroblasts in mesenchymal tissue and glandular cells in the gallbladder. We were unable to detect C-Reactive Protein / CRP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of C-Reactive Protein / CRP expression as measured by anti-C-Reactive Protein / CRP antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | ++ | – | – | – | – | + | – | – | – | – | – | – | – |
| CRP Variability | + | ++ | + | ++ | + | + | ++ | +++ | ++ | ++ | + | ++ | ++ | + | ++ | + | + | + | ++ | ++ |
| C-Reactive Protein / CRP General Information | |
|---|---|
| Alternate Names | |
| C-Reactive Protein, CRP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CRP |
| Entrez Gene ID | 1401 |
| Ensemble Gene ID | ENSG00000132693 |
| RefSeq Protein Accession(s) | NP_001315987, NP_001315986, XP_011507509, NP_000558 |
| RefSeq mRNA Accession(s) | NM_001329058 NM_001329057, NM_000567, XM_011509207 |
| RefSeq Genomic Accession(s) | NC_018912, NG_013007, NC_000001 |
| UniProt ID(s) | P02741 |
| UniGene ID(s) | P02741 |
| HGNC ID(s) | 2367 |
| Cosmic ID(s) | CRP |
| KEGG Gene ID(s) | hsa:1401 |
| PharmGKB ID(s) | PA120 |
| General Description of C-Reactive Protein / CRP. | |
| C-reactive protein (CRP) is a protein found in the blood which is measured in the plasma. Its levels rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.
CRP is used mainly as a marker of inflammation. The level of C-reactive protein (CRP) which can be measured in human blood increases in the presence of inflammation. Because CRP does not remain in the area of inflammation, a CRP test can only reveal inflammation but is not location specific. It is often measured to indicate the presence of particular disease or the effectiveness of treatments. A high-sensitivity C-reactive protein test (hs-CRP), also can be used to identify coronary artery disease. However, a low CRP level does not always indicate the absence of inflammation. Levels of CRP may not be increased in people with autimmune diseases like rheumatoid arthritis and lupus. |
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