PDF DatasheetHuman and Horse Anti-Carbonic Anhydrase IX Antibody Product Attributes
Carbonic Anhydrase IX Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CA9 antibody staining is expected to be primarily localized to the plasma membrane and cytosol.
Observed Antibody Staining Data By Tissue Type:
Variations in Carbonic Anhydrase IX antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the gallbladder, stomach. More moderate antibody staining intensity was present in glandular cells in the gallbladder, stomach. Low, but measureable presence of Carbonic Anhydrase IX could be seen in. We were unable to detect Carbonic Anhydrase IX in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Carbonic Anhydrase IX expression as measured by anti-Carbonic Anhydrase IX antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| CA9 Variability | + | + | + | + | + | + | + | + | + | + | + | + | + | + | ++ | + | ++ | + | + | ++ |
| Carbonic Anhydrase IX General Information | |
|---|---|
| Alternate Names | |
| Carbonic anhydrase 9, CA9, CAIX | |
| Molecular Weight | |
| 55kDa | |
| Chromosomal Location | |
| 9p13.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CA9 |
| Entrez Gene ID | 768 |
| Ensemble Gene ID | ENSG00000107159 |
| RefSeq Protein Accession(s) | NP_001207 |
| RefSeq mRNA Accession(s) | XR_428428, NM_001216, XR_001746374 |
| RefSeq Genomic Accession(s) | NC_000009, NC_018920 |
| UniProt ID(s) | A0A0S2Z3D0, Q16790 |
| UniGene ID(s) | A0A0S2Z3D0, Q16790 |
| HGNC ID(s) | 1383 |
| Cosmic ID(s) | CA9 |
| KEGG Gene ID(s) | hsa:768 |
| PharmGKB ID(s) | PA25998 |
| General Description of Carbonic Anhydrase IX. | |
| Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Carbonic Anhydrases (CAs) are members of a large family of zinc metallo-enzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, the formation of aqueous humor, cerebrospinal fluid, saliva, gastric juice. They show extensive diversity in distribution, in their subcellular localization. CA IX is specifically expressed in clear-cell renal carcinomas. | |
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