PDF DatasheetHuman Anti-Catenin, gamma Antibody Product Attributes
Catenin, gamma Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-JUP antibody staining is expected to be primarily localized to the cell junctions, plasma membrane and vesicles.
Observed Antibody Staining Data By Tissue Type:
Variations in Catenin, gamma antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in bile duct cells in the liver, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the appendix, breast, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, keratinocytes in skin, myocytes in heart muscle, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in bile duct cells in the liver, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the appendix, breast, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, keratinocytes in skin, myocytes in heart muscle, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. Low, but measureable presence of Catenin, gamma could be seen in cells in the endometrial stroma in endometrium, fibroblasts in mesenchymal tissue, germinal center cells in the tonsil, hematopoietic cells in the bone marrow, macrophages in lung and pneumocytes in lung. We were unable to detect Catenin, gamma in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Catenin, gamma expression as measured by anti-Catenin, gamma antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | ++ | ++ | +++ | +++ | +++ | – | ++ | ++ | ++ | – | + | +++ | +++ | +++ | ++ | +++ | ++ | ++ | ++ | +++ |
| JUP Variability | + | ++ | ++ | + | ++ | + | ++ | ++ | ++ | + | ++ | ++ | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ |
| Catenin, gamma General Information | |
|---|---|
| Alternate Names | |
| JUP, Plakoglobin, Junction plakoglobin, Gamma-catenin | |
| Molecular Weight | |
| 80-87kDa | |
| Chromosomal Location | |
| 17q21 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | JUP |
| Entrez Gene ID | 3728 |
| Ensemble Gene ID | ENSG00000173801 |
| RefSeq Protein Accession(s) | XP_011523060, NP_001339704, NP_001339705, NP_002221, XP_006721938, XP_011523058, XP_016880079, NP_001339703, XP_006721936, XP_006721937, XP_006721941, XP_016880077, XP_016880078, NP_068831, XP_011523059, XP_011523055, NP_001339706, XP_011523057, NP_001339702 |
| RefSeq mRNA Accession(s) | XM_017024588, NM_021991, XM_006721873, XM_011524757, XM_011524753, XM_017024590, NM_001352773, XM_011524755, XM_017024589, NM_001352777, NM_002230, NM_001352774, NM_001352776, XM_006721875, XM_006721878, XM_011524756, XM_011524758, NM_001352775 |
| RefSeq Genomic Accession(s) | NC_000017, NG_009090, NC_018928 |
| UniProt ID(s) | A0A0S2Z487, P14923 |
| UniGene ID(s) | A0A0S2Z487, P14923 |
| HGNC ID(s) | 6207 |
| Cosmic ID(s) | JUP |
| KEGG Gene ID(s) | hsa:3728 |
| PharmGKB ID(s) | PA30009 |
| General Description of Catenin, gamma. | |
| This MAb recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (?, ?, ? and ?) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. ? T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. ? T-catenin binds to ? E-catenin as well as to ?-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for ?-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy. | |
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