PDF DatasheetHuman Anti-CD162 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD162 Antibody Clone: PSGL1/1601
Clone PSGL1/1601 Host and Isotype: Mouse IgG1
Anti-Human CD162 Positive Control Sample: Jurkat cells. Tonsil or Spleen
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length SELPLG (CD162) protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD162 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD162 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD162 could be seen inlymphoid tissue in appendix, hematopoietic cells in the bone marrow and germinal center cells in the tonsil. We were unable to detect CD162 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD162 General Information | |
|---|---|
| Alternate Names | |
| Selectin P ligand, SELPLG, CD162, cluster of differentiation 162, P Selectin Ligand | |
| Molecular Weight | |
| 43-120kDa | |
| Chromosomal Location | |
| 12q24 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SELPLG |
| Entrez Gene ID | 6404 |
| Ensemble Gene ID | ENSG00000110876 |
| RefSeq Protein Accession(s) | NP_002997, NP_001193538 |
| RefSeq mRNA Accession(s) | NM_001206609, NM_003006 |
| RefSeq Genomic Accession(s) | NC_000012, NC_018923 |
| UniProt ID(s) | Q14242 |
| UniGene ID(s) | Q14242 |
| HGNC ID(s) | 10722 |
| Cosmic ID(s) | SELPLG |
| KEGG Gene ID(s) | hsa:6404 |
| PharmGKB ID(s) | PA35644 |
| General Description of CD162. | |
| CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. | |
Limitations and Warranty
enQuire Bio’s CD162 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
There are no reviews yet.