PDF DatasheetHuman Anti-CD19 / Leu-12 Antibody Product Attributes
CD19 / Leu-12 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD19 / Leu-12 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen, cells in the white pulp in spleen, germinal center cells in the lymph node and tonsil, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the red pulp in spleen, cells in the white pulp in spleen, germinal center cells in the lymph node and tonsil, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD19 / Leu-12 could be seen in. We were unable to detect CD19 / Leu-12 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD19 / Leu-12 General Information | |
|---|---|
| Alternate Names | |
| CD19, Leu-12, B4, CVID3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD19 |
| Entrez Gene ID | 930 |
| Ensemble Gene ID | ENSG00000177455 |
| RefSeq Protein Accession(s) | XP_011544283, NP_001761, XP_006721166, XP_016879382, NP_001171569 |
| RefSeq mRNA Accession(s) | XM_017023893, NM_001770, XM_006721103, XM_011545981, XR_950871 NM_001178098 |
| RefSeq Genomic Accession(s) | NC_018927, NG_007275, NC_000016 |
| UniProt ID(s) | P15391 |
| UniGene ID(s) | P15391 |
| HGNC ID(s) | 1633 |
| Cosmic ID(s) | CD19 |
| KEGG Gene ID(s) | hsa:930 |
| PharmGKB ID(s) | PA26192 |
| General Description of CD19 / Leu-12. | |
| The SJ25C1 antibody reacts with human CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 (CR2), CD81 (TAPA-1) and CD225 (Leu13), in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. Upon activation and tyrosine phosphorylation, the CD19 molecule can provide an anchor for cytoplasmic signaling proteins such as GRB2, SOS or PLCG2. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.The SJ25C1 antibody is widely used as a phenotypic marker for CD19 expression on B cells, as well as on dendritic cell subsets. | |
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