DISC: CD1a [O10] Antibody

SKU: QIVD89
Species: Human
Tested Applications: IHC [IVD]
Available Conjugates:
Isotype: Mouse IgG1, kappa

PDF Datasheet

Discontinued

Antibody (Suitable for clinical applications)

Sample Type: FFPE Patient Samples.

Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.

Application Notes

Specification	Recommendation
Recommended Dilution (Conc)	1:25-1:50
Pretreatment	EDTA Buffer pH 8.0
Incubation Parameters	30 min at Room Temperature

Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.

Clonality: Monoclonal

Anti-CD1a Antibody Clone: O10

Host and Isotype: Mouse IgG1, kappa

Recommended Positive Control Sample: Tonsil

Cellular Localization of Antibody O10 Staining: Cytoplasmic, cell membrane

Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN₃

Antibody Concentration: Lot specific. Plese contact tech support for data.

Immunogen: BALB/C mice were injected with thymus cells.

Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.

CD1a Information for Pathologists

Summary:

CD1a is a T cell surface antigen found on subsets of normal T cells. It is important in antigen presentation to dendritic cells, particularly glycolipids and lipopeptide antigens that traffic through early endocytic pathways. CD1a is also referred to as Leu6.

Common Uses By Pathologists:

CD1a immunostaining is used to diagnose Langerhans cell histiocytosis and to exclude other entities that are CD1a negative. It is also a useful means of identifying Langerhans cells in inflammatory or neoplastic disorders.

CD1a General Information
Alternate Names

Molecular Weight
37.1 kDa
Chromosomal Location
q23.1 [chr: 1] [chr_start: 158254424] [chr_end: 158258269] [strand: 1]
Curated Database and Bioinformatic Data
Gene Symbol	CD1A
Entrez Gene ID	909
RefSeq Protein Accession(s)	NP_001307581; NP_001754
RefSeq mRNA Accession(s)	NM_001320652; XM_024450738; NM_001763
RefSeq Genomic Accession(s)	NC_000001
UniProt ID(s)	P06126
PharmGKB ID(s)	PA26193
KEGG Gene ID(s)	hsa:909
General Description of CD1a .
This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.

Limitations and Warranty

This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.

Size	0.1 ml, 0.5 ml, 1 ml
Tag	Unconjugated
Buffer and Stabilizer	PBS with 1% BSA and 0.05% NaN3
Product Type	Antibody
Host	Mouse
Isotype	IgG1, kappa
Applications	IHC
Species	Human
Format	Concentrate

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