PDF DatasheetHuman Anti-CD2 / LY37 Antibody Product Attributes
CD2 / LY37 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD2 / LY37 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the white pulp in spleen. More moderate antibody staining intensity was present in cells in the white pulp in spleen. Low, but measureable presence of CD2 / LY37 could be seen in. We were unable to detect CD2 / LY37 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of CD2 / LY37 expression as measured by anti-CD2 / LY37 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | + | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | + |
| CD2 Variability | + | ++ | + | ++ | + | + | ++ | + | ++ | ++ | + | + | + | + | + | + | + | ++ | ++ | +++ |
| CD2 / LY37 General Information | |
|---|---|
| Alternate Names | |
| CD2, LY37, OX-34, CD2R, LFA-2, LFA2, OX34 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD2 |
| Entrez Gene ID | 914 |
| Ensemble Gene ID | ENSG00000116824 |
| RefSeq Protein Accession(s) | NP_001315538, NP_001758 |
| RefSeq mRNA Accession(s) | NM_001767, NM_001328609 |
| RefSeq Genomic Accession(s) | NC_000001, NC_018912, NG_050908 |
| UniProt ID(s) | Q53F96, P06729 |
| UniGene ID(s) | Q53F96, P06729 |
| HGNC ID(s) | 1639 |
| Cosmic ID(s) | CD2 |
| KEGG Gene ID(s) | hsa:914 |
| PharmGKB ID(s) | PA26198 |
| General Description of CD2 / LY37. | |
| The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.RPA-2.10 is reported to block mixed lymphocyte reaction. Please choose the appropriate format for each application. | |
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Limitations and Warranty
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