PDF DatasheetHuman Anti-CD209 / DC-SIGN Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD209 / DC-SIGN Antibody Clone: C209/1781
Clone C209/1781 Host and Isotype: Mouse IgG2b kappa
Anti-Human CD209 / DC-SIGN Positive Control Sample: THP-1 or HeLa Cells. Small Intestine, Uterus or Lymph Node.
Cellular Localization of Antibody Secreted and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CD209 protein fragment
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD209 / DC-SIGN Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD209 / DC-SIGN antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD209 / DC-SIGN could be seen in. We were unable to detect CD209 / DC-SIGN in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD209 / DC-SIGN General Information | |
|---|---|
| Alternate Names | |
| DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin, CD209, Cluster of Differentiation 209, | |
| Molecular Weight | |
| 45kDa | |
| Chromosomal Location | |
| 19p13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD209 |
| Entrez Gene ID | 30835 |
| Ensemble Gene ID | ENSG00000090659 |
| RefSeq Protein Accession(s) | NP_001138366, NP_001138368, NP_001138369, NP_001138365, XP_005272529, NP_001138367, NP_066978, NP_001138371 |
| RefSeq mRNA Accession(s) | NM_001144897, NM_001144899, XM_005272472, NM_001144894, NM_001144895 NM_001144893, NM_001144896, NR_026692, NM_021155 |
| RefSeq Genomic Accession(s) | NC_018930, NC_000019, NG_012167 |
| UniProt ID(s) | B2R907, X6RB12, Q9NNX6, M0R0P0, B4E2A8 |
| UniGene ID(s) | B2R907, X6RB12, Q9NNX6, M0R0P0, B4E2A8 |
| HGNC ID(s) | 1641 |
| Cosmic ID(s) | CD209 |
| KEGG Gene ID(s) | hsa:30835 |
| PharmGKB ID(s) | PA26199 |
| General Description of CD209 / DC-SIGN. | |
| DC-SIGN is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and enCanineenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity. | |
Limitations and Warranty
enQuire Bio’s CD209 / DC-SIGN Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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