PDF DatasheetHuman Anti-CD27 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD27 Antibody Clone: LPFS2/1611
Clone LPFS2/1611 Host and Isotype: Mouse IgG1
Anti-Human CD27 Positive Control Sample: Human peripheral blood lymphocytes. Human tonsil and lymph node.
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CD22 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD27 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD27 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD27 could be seen ingerminal center cells in the lymph node and tonsil and hematopoietic cells in the bone marrow. We were unable to detect CD27 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD27 General Information | |
|---|---|
| Alternate Names | |
| CD27, TNFRSF7, TNFSF7 | |
| Molecular Weight | |
| 120kDa | |
| Chromosomal Location | |
| 12p13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD27 |
| Entrez Gene ID | 939 |
| Ensemble Gene ID | ENSG00000139193 |
| RefSeq Protein Accession(s) | XP_011519344, NP_001233, XP_016875722, XP_016875721, XP_016875723 |
| RefSeq mRNA Accession(s) | XM_017020232, NM_001242, XM_017020233, XM_011521042, XM_017020234 |
| RefSeq Genomic Accession(s) | NC_000012, NG_031995, NC_018923 |
| UniProt ID(s) | P26842 |
| UniGene ID(s) | P26842 |
| HGNC ID(s) | 11922 |
| Cosmic ID(s) | CD27 |
| KEGG Gene ID(s) | hsa:939 |
| PharmGKB ID(s) | PA162382107 |
| General Description of CD27. | |
| Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NF?B and SAPK/JNK and induces apoptosis. | |
Limitations and Warranty
enQuire Bio’s CD27 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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