PDF DatasheetHuman Anti-CD56 Antibody Product Attributes
CD56 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Staining with anti-CD56 antibody reveals CD56 expression is expected to be primarily localized to the cytosol and plasma membrane.
Observed Antibody Staining Data By Tissue Type:
Variations in CD56 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in neuropil in cerebral cortex and peripheral nerve/ganglion in colon. More moderate antibody staining intensity was present in neuropil in cerebral cortex and peripheral nerve/ganglion in colon. Low, but measureable presence of CD56 could be seen inglial cells in the hippocampus, exocrine glandular cells in the pancreas and smooth muscle cells in the smooth muscle. We were unable to detect CD56 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of CD56 expression as measured by anti-CD56 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | ++ | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| NCAM1 Variability | + | ++ | + | + | + | ++ | + | + | + | + | + | ++ | + | + | + | + | + | + | ++ | + |
| CD56 General Information | |
|---|---|
| Alternate Names | |
| NCAM, Neural Cell Adhesion Molecule | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NCAM1 |
| Entrez Gene ID | 4684 |
| Ensemble Gene ID | ENSG00000149294 |
| RefSeq Protein Accession(s) | NP_001229536, NP_851996, NP_001070150, NP_001229537, NP_000606 |
| RefSeq mRNA Accession(s) | NM_001076682, NM_001242607, NM_001242608, NM_181351 NM_000615 |
| RefSeq Genomic Accession(s) | NC_000011, NG_032036, NC_018922 |
| UniProt ID(s) | P13591, A0A087WWD4 |
| UniGene ID(s) | P13591, A0A087WWD4 |
| HGNC ID(s) | 7656 |
| Cosmic ID(s) | NCAM1 |
| KEGG Gene ID(s) | hsa:4684 |
| PharmGKB ID(s) | PA31459 |
| General Description of CD56. | |
| The MY31 antibody reacts with human CD56, also known as the neural cell adhesion molecule (NCAM), a glycoprotein which is a member of the immunoglobulin superfamily. The 140 kDa isoform of CD56 is expressed on human NK cells and NK-T cells, with increased expression levels on activated NK lymphocytes. The CD56 antigen is also expressed by neurons and is reported to play a role in nervous system development and neural cell-to-cell adhesion. Clone MY31 also reacts with a subset of CD14+ monocytes in non-human primates, and is reported to be cross-reactive with Chimpanzee, Cynomolgus and Rhesus. | |
Selected References
Limitations and Warranty
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