PDF DatasheetHuman Anti-CD61 / Integrin beta-3 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD61 / Integrin beta-3 Antibody Clone: Y2/51
Clone Y2/51 Host and Isotype: Mouse IgG1 kappa
Anti-Human CD61 / Integrin beta-3 Positive Control Sample: U937, KG1a, HEL cells. Spleen
Cellular Localization of Antibody Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Phytohemagglutinin (PHA)-stimulated peripheral blood cells
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD61 / Integrin beta-3 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD61 / Integrin beta-3 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow. Low, but measureable presence of CD61 / Integrin beta-3 could be seen in. We were unable to detect CD61 / Integrin beta-3 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD61 / Integrin beta-3 General Information | |
|---|---|
| Alternate Names | |
| Integrin beta-3, Integrin ?3), Integrin B3, CD61, ITGB3 | |
| Molecular Weight | |
| 105kDa ;90kDa | |
| Chromosomal Location | |
| 17q21.32 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ITGB3 |
| Entrez Gene ID | 3690 |
| Ensemble Gene ID | ENSG00000259207 |
| RefSeq Protein Accession(s) | NP_000203 |
| RefSeq mRNA Accession(s) | NM_000212 |
| RefSeq Genomic Accession(s) | NC_000017, NC_018928, NG_008332 |
| UniProt ID(s) | P05106 |
| UniGene ID(s) | P05106 |
| HGNC ID(s) | 6156 |
| Cosmic ID(s) | ITGB3 |
| KEGG Gene ID(s) | hsa:3690 |
| PharmGKB ID(s) | PA205 |
| General Description of CD61 / Integrin beta-3. | |
| Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the ?V-chain (CD51) to form vitronectin receptor, or with the ?IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia. | |
Limitations and Warranty
enQuire Bio’s CD61 / Integrin beta-3 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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