PDF DatasheetHuman Anti-CD71 / Transferrin Receptor Antibody Product Attributes
CD71 / Transferrin Receptor Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-TFRC antibody staining is expected to be primarily localized to the endosomes and lysosomes.
Observed Antibody Staining Data By Tissue Type:
Variations in CD71 / Transferrin Receptor antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in hematopoietic cells in the bone marrow and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in hematopoietic cells in the bone marrow and trophoblastic cells in the placenta. Low, but measureable presence of CD71 / Transferrin Receptor could be seen inlymphoid tissue in appendix, glandular cells in the breast, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus, neuronal cells in the caudate nucleus, cells in the granular layer in cerebellum, neuronal cells in the cerebral cortex, squamous epithelial cells in the cervix, uterine, glandular cells in the endometrium, epididymis and gallbladder, myocytes in heart muscle, hepatocytes in liver, respiratory epithelial cells in the nasopharynx, follicle cells in the ovary, ovarian stroma cells in the ovary, exocrine glandular cells in the pancreas, islets of Langerhans in pancreas, glandular cells in the parathyroid gland and prostate, keratinocytes in skin, melanocytes in skin, glandular cells in the small intestine, smooth muscle cells in the smooth muscle, peripheral nerve in mesenchymal tissue, glandular cells in the stomach, Leydig cells in the testis and non-germinal center cells in the tonsil. We were unable to detect CD71 / Transferrin Receptor in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of CD71 / Transferrin Receptor expression as measured by anti-CD71 / Transferrin Receptor antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | ++ | – | ++ | ++ | ++ | ++ | +++ | + | + | + | + | ++ | + | – | – | ++ | – | – | – | ++ |
| TFRC Variability | ++ | + | ++ | + | ++ | ++ | + | ++ | +++ | ++ | ++ | ++ | ++ | + | ++ | ++ | ++ | + | ++ | ++ |
| CD71 / Transferrin Receptor General Information | |
|---|---|
| Alternate Names | |
| Transferrin receptor protein 1, TfR1, Cluster of Differentiation 71, CD71, TFRC | |
| Molecular Weight | |
| 85-95kDa (monomer) ;190kDa (dimer) | |
| Chromosomal Location | |
| 3q29 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TFRC |
| Entrez Gene ID | 7037 |
| Ensemble Gene ID | ENSG00000072274 |
| RefSeq Protein Accession(s) | NP_001121620, NP_001300895, NP_003225, NP_001300894 |
| RefSeq mRNA Accession(s) | NM_001313965, NM_003234, NM_001128148, NM_001313966, |
| RefSeq Genomic Accession(s) | NG_046395, NC_000003, NC_018914 |
| UniProt ID(s) | A8K6Q8, Q7Z3E0, B7Z2I6, P02786, G3V0E5 |
| UniGene ID(s) | A8K6Q8, Q7Z3E0, B7Z2I6, P02786, G3V0E5 |
| HGNC ID(s) | 11763 |
| Cosmic ID(s) | TFRC |
| KEGG Gene ID(s) | hsa:7037 |
| PharmGKB ID(s) | PA36478 |
| General Description of CD71 / Transferrin Receptor. | |
| This MAb recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. | |
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