PDF DatasheetHuman Anti-CD8A Antibody Product Attributes
CD8A Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD8A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the red pulp in spleen, cells in the white pulp in spleen, lymphoid tissue in appendix and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of CD8A could be seen inmacrophages in lung. We were unable to detect CD8A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD8A General Information | |
|---|---|
| Alternate Names | |
| CD8a, Cluster of Differentiation 8a, Often just referred to as CD8 | |
| Molecular Weight | |
| 32kDa | |
| Chromosomal Location | |
| 2p11.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CD8A |
| Entrez Gene ID | 925 |
| Ensemble Gene ID | ENSG00000153563 |
| RefSeq Protein Accession(s) | NP_001759, NP_001139345, NP_741969 |
| RefSeq mRNA Accession(s) | NM_001145873, NM_001768, NM_171827, NR_027353, |
| RefSeq Genomic Accession(s) | NC_000002, NG_011608, NC_018913 |
| UniProt ID(s) | P01732, Q8TAW8, Q6ZVS2 |
| UniGene ID(s) | P01732, Q8TAW8, Q6ZVS2 |
| HGNC ID(s) | 1706 |
| Cosmic ID(s) | CD8A |
| KEGG Gene ID(s) | hsa:925 |
| PharmGKB ID(s) | PA26244 |
| General Description of CD8A. | |
| CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. | |
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