![Analysis of Mass Spec data (dashed-line) of fractions stained with Cdk1 / p34cdc2 MS-QAVA™ monoclonal antibody [Clone: CDK1/873] (solid-line), reveals that less than 1.4% of signal is attributable to non-specific binding of anti-Cdk1 / p34cdc2 [Clone CDK1/873] to targets other than CDC2 protein. Even frequently cited antibodies have much greater non-specific interactions, averaging over 30%. Data in image is from analysis in Jurkat, U202 and HeLa cells.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2017/10/enQuire-Bio-983-MSM2-P1-anti-Cdk1-p34cdc2-antibody.png "Cdk1 / p34cdc2 Antibody Mass Spec Validation Data")
PDF DatasheetHuman Anti-Cdk1 / p34cdc2 Antibody Product Attributes
Species: Human. Does not react with Mouse or Rat.
Predicted Cross Reactivity: Monkey, Bovine, Mink, Xenopus, Drosophila, S pombe, and S cerevisiae
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC). Additionally, this antibody has been validated by MS-QAVA™. Specificity has been quantitatively determined via Mass Spec.
Clonality: Monoclonal
Anti-Cdk1 / p34cdc2 Antibody Clone: CDK1/873
Clone CDK1/873 Host and Isotype: Mouse IgG2a kappa
Anti-Human, Monkey, Bovine, Mink, Mouse (-), Rat (-), Xenopus, Drosophila, S pombe, and S cerevisiae Cdk1 / p34cdc2 Positive Control Sample: HeLa Cells or Tonsil
Cellular Localization of Antibody Nuclear, Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CDK1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Cdk1 / p34cdc2 Previously Observed Antibody Staining Patterns
| Cdk1 / p34cdc2 General Information | |
|---|---|
| Alternate Names | |
| Cdc2, CDC28A, CDK1, CDKN1, CELL CYCLE CONTROLLER CDC2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S, G2 to M, Cell division protein kinase 1, Cyclin-dependent kinase 1, p34 Protein Kinase, P34CDC2, anti-Cdc2 antibody, anti-CDC28A antibody, anti-CDK1 antibody, anti-CDKN1 antibody, anti-CELL CYCLE CONTROLLER CDC2 antibody, anti-Cell division control protein 2 homolog antibody, anti-Cell division cycle 2 G1 to S, G2 to M antibody, anti-Cell division protein kinase 1 antibody, anti-Cyclin-dependent kinase 1 antibody, anti-p34 Protein Kinase antibody, and anti-P34CDC2 antibody | |
| Molecular Weight | |
| 34kDa | |
| Chromosomal Location | |
| 10q21.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CDC2 |
| Entrez Gene ID | 983 |
| Ensemble Gene ID | ENSG00000170312 |
| RefSeq Protein Accession(s) | NP_001163877, NP_203698, NP_001777, XP_005270360, NP_001307847, NP_001163878 |
| RefSeq mRNA Accession(s) | NM_001170407, XM_005270303, NM_001170406, NM_033379 NM_001786, NM_001130829, NM_001320918 |
| RefSeq Genomic Accession(s) | NG_029877, NC_000010, NC_018921 |
| UniProt ID(s) | B7Z3D6, P06493, A0A024QZJ8, I6L9I5 |
| UniGene ID(s) | B7Z3D6, P06493, A0A024QZJ8, I6L9I5 |
| HGNC ID(s) | 1722 |
| Cosmic ID(s) | CDK1 |
| KEGG Gene ID(s) | hsa:983 |
| PharmGKB ID(s) | PA99 |
| General Description of Cdk1 / p34cdc2. | |
| Recognizes a 34kDa protein, which is identified as cyclin dependent kinase 1 (cdk1) or p34cdc2 protein kinase. cdk1 / p34cdc2 plays a crucial role during cell division, is most active during mitosis. It is predominantly localized in the nucleus. It is a serine/threonine kinase, which is activated by cyclin, presumably by de-phosphorylation of tyrosine residues. Activated cdk1 / p34cdc2 performs specific functions during mitosis, including nuclear envelope breakdown, chromosome condensation. | |
Limitations and Warranty
This product is for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
![Analysis of Mass Spec data (dashed-line) of fractions stained with Cdk1 / p34cdc2 MS-QAVA™ monoclonal antibody [Clone: POH-1; same as cdc2.1] (solid-line), reveals that less than 1.6% of signal is attributable to non-specific binding of anti-Cdk1 / p34cdc2 [Clone POH-1; cdc2.1] to targets other than CDC2 protein. Even frequently cited antibodies have much greater non-specific interactions, averaging over 30%. Data in image is from analysis in Jurkat, U202 and HeLa cells.](https://cdn-enquirebio.pressidium.com/wp-content/uploads/2017/10/enQuire-Bio-983-MSM1-P1-anti-Cdk1-p34cdc2-antibody-150x150.png)
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