PDF DatasheetHuman Anti-CDX2 Antibody Product Attributes
CDX2 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CDX2 antibody staining is expected to be primarily localized to the nucleoplasm. There is variability in either the signal strength or the localization of signal in nucleoplasm from cell to cell.
Observed Antibody Staining Data By Tissue Type:
Variations in CDX2 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in glandular cells in the appendix, colon, duodenum, rectum. More moderate antibody staining intensity was present in glandular cells in the appendix, colon, duodenum, rectum. Low, but measureable presence of CDX2 could be seen in. We were unable to detect CDX2 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CDX2 General Information | |
|---|---|
| Alternate Names | |
| Homeobox protein CDX-2, CDX2 | |
| Molecular Weight | |
| 40kDa | |
| Chromosomal Location | |
| 13q12.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CDX2 |
| Entrez Gene ID | 1045 |
| Ensemble Gene ID | ENSG00000165556 |
| RefSeq Protein Accession(s) | XP_011533179, XP_011533181, NP_001256, NP_001341629, XP_011533177, XP_011533180, XP_011533178 |
| RefSeq mRNA Accession(s) | XM_011534875, XM_011534878, NM_001265, XM_011534876, XM_011534879, XM_011534877, NM_001354700 |
| RefSeq Genomic Accession(s) | NC_018924, NC_000013, |
| UniProt ID(s) | Q99626 |
| UniGene ID(s) | Q99626 |
| HGNC ID(s) | 1806 |
| Cosmic ID(s) | CDX2 |
| KEGG Gene ID(s) | hsa:1045 |
| PharmGKB ID(s) | PA26352 |
| General Description of CDX2. | |
| The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary. | |
There are no reviews yet.