PDF DatasheetHuman Anti-CELA3B / ELA3B Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CELA3B / ELA3B Antibody Clone: CELA3B/1757
Clone CELA3B/1757 Host and Isotype: Mouse IgG1 kappa
Anti-Human CELA3B / ELA3B Positive Control Sample: Panc-28 or PANC1 cells. Pancreas
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human CELA3B protein fragment (aa82-238)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CELA3B / ELA3B Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CELA3B antibody staining is expected to be primarily localized to the cytosol.
| CELA3B / ELA3B General Information | |
|---|---|
| Alternate Names | |
| Chymotrypsin-like elastase family member 3B, elastase-3B, protease E, fecal elastase | |
| Molecular Weight | |
| 17kDa | |
| Chromosomal Location | |
| 1p36.12 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CELA3B |
| Entrez Gene ID | 23436 |
| Ensemble Gene ID | ENSG00000219073 |
| RefSeq Protein Accession(s) | NP_031378 |
| RefSeq mRNA Accession(s) | NM_007352 |
| RefSeq Genomic Accession(s) | NC_000001, NC_018912 |
| UniProt ID(s) | P08861 |
| UniGene ID(s) | P08861 |
| HGNC ID(s) | 15945 |
| Cosmic ID(s) | CELA3B |
| KEGG Gene ID(s) | hsa:23436 |
| PharmGKB ID(s) | PA27737 |
| General Description of CELA3B / ELA3B. | |
| This MAb recognizes a protein of ~30kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein ;it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function. | |
Limitations and Warranty
enQuire Bio’s CELA3B / ELA3B Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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