PDF DatasheetHuman and Mouse Anti-CFTR Antibody Product Attributes
CFTR Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CFTR antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CFTR could be seen inglandular cells in the salivary gland. We were unable to detect CFTR in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of CFTR expression as measured by anti-CFTR antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| CFTR Variability | + | ++ | + | + | + | + | + | + | + | + | + | + | ++ | + | + | + | + | + | + | + |
| CFTR General Information | |
|---|---|
| Alternate Names | |
| Cystic fibrosis transmembrane conductance regulator, CFTR | |
| Molecular Weight | |
| 165-170kDa | |
| Chromosomal Location | |
| 7q31.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CFTR |
| Entrez Gene ID | 1080 |
| Ensemble Gene ID | ENSG00000001626 |
| RefSeq Protein Accession(s) | XP_011514055, NP_000483, XP_016867188, XP_011514053, XP_011514056 |
| RefSeq mRNA Accession(s) | XM_011515753, XM_017011699, XM_011515754, NM_000492 |
| RefSeq Genomic Accession(s) | NG_016465, NC_018918, NC_000007 |
| UniProt ID(s) | A0A024R730, P13569 |
| UniGene ID(s) | A0A024R730, P13569 |
| HGNC ID(s) | 1884 |
| Cosmic ID(s) | CFTR |
| KEGG Gene ID(s) | hsa:1080 |
| PharmGKB ID(s) | PA109 |
| General Description of CFTR. | |
| Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3′,5′-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. | |
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