PDF DatasheetHuman Anti-Clathrin, Light Chain Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Clathrin, Light Chain Antibody Clone: SPM174
Clone SPM174 Host and Isotype: Mouse IgG2b kappa
Anti-Human Clathrin, Light Chain Positive Control Sample: HeLa cells. Placenta or Prostate Carcinoma.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Purified recombinant N-terminal fragment of human Clathrin Light Chain
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Clathrin, Light Chain Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CLTA and CLTB antibody staining is expected to be primarily localized to the endosomes and lysosomes.
| Clathrin, Light Chain General Information | |
|---|---|
| Alternate Names | |
| Serum amyloid A1, SAA1, SAA1 | |
| Molecular Weight | |
| 31-44kDa | |
| Chromosomal Location | |
| 9p13.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CLTA and CLTB |
| Entrez Gene ID | 1211, 1212 |
| Ensemble Gene ID | ENSG00000122705, ENSG00000175416 |
| RefSeq Protein Accession(s) | NP_001070145, NP_001298132, NP_001171690, XP_016869747, NP_001171689, NP_001298133, NP_001298135, XP_016869746, NP_001298134, NP_009027, NP_001171691, NP_001824, NP_001825, XP_016864516, NP_009028, XP_016864515 |
| RefSeq mRNA Accession(s) | XM_017014257, NM_001311204, NM_001076677, NM_001184762, NR_132349, NM_001184760, NM_001311203, NM_001311205, NM_001311206, XM_017014258, NM_001184761, NM_001833, NM_007096, XR_001741996, NM_007097, NM_001834, XM_017009026, XM_017009027, XR_001741995, NR_045724 |
| RefSeq Genomic Accession(s) | NC_018920, NC_000009NC_018916, NC_000005 |
| UniProt ID(s) | P09496, C9J8P9, B4DTF9, A0A024R7S3, 90497 |
| UniGene ID(s) | P09496, C9J8P9, B4DTF9, A0A024R7S3, 90497 |
| HGNC ID(s) | 2090, 2091 |
| Cosmic ID(s) | CLTA, CLTB |
| KEGG Gene ID(s) | hsa:1211, hsa:1212 |
| PharmGKB ID(s) | PA26616, PA26617 |
| General Description of Clathrin, Light Chain. | |
| Recognizes proteins of 31-44kDa, which are identified as Clathrin Light Chains (both A ;B). Clathrin is composed of three heavy chains and three light chains, which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology, and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing, which results in the generation of tissue-specific isoforms. | |
Limitations and Warranty
enQuire Bio’s Clathrin, Light Chain Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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