PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:75 |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Cytokeratin 15 Information for Pathologists
Summary:
Molecular weight of 50 kDa. Downregulated in activated keratinocytes in psoriasis, hypertrophic scars and skin injury (J Invest Dermatol 1999;112:362, Exp Cell Res 2000;254:80). Uses by pathologists No significant clinical use by pathologists. Positive staining – normal
Common Uses By Pathologists:
No significant clinical use by pathologists. Positive staining – normal Conjunctiva (basal cells) and cornea limbus epithelial cells (basal and suprabasal cells, Invest Ophthalmol Vis Sci 2006;47:4780). Esophagus-Mol Cell Biol 2004;24:3168). Fetal epidermis and nail, hair follicle bulge and follicular stem cells (Clin Exp Dermatol 2006;31:807).
| Cytokeratin 15 General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 49.2 kDa | |
| Chromosomal Location | |
| q21.2 [chr: 17] [chr_start: 41513745] [chr_end: 41522529] [strand: -1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KRT15 |
| Entrez Gene ID | 3866 |
| RefSeq Protein Accession(s) | NP_002266 |
| RefSeq mRNA Accession(s) | ; XM_011524784; XM_017024614; NM_002275 |
| RefSeq Genomic Accession(s) | NG_012284; NC_000017 |
| UniProt ID(s) | P19012 |
| PharmGKB ID(s) | PA30208 |
| KEGG Gene ID(s) | hsa:3866 |
| General Description of Cytokeratin 15 . | |
| Cytokeratin 15 is a type I cytokeratin without a defined type II partner. Cytokeratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. | |
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