PDF DatasheetHuman and Mouse Anti-Cytokeratin 6 Antibody Product Attributes
Species: Human and Mouse
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Cytokeratin 6 Antibody Clone: KRT6/1702
Clone KRT6/1702 Host and Isotype: Mouse IgG2a kappa
Anti-Human and Mouse Cytokeratin 6 Positive Control Sample: Tonsil or basal cell carcinoma
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length keratin 6 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Cytokeratin 6 Previously Observed Antibody Staining Patterns
| Cytokeratin 6 General Information | |
|---|---|
| Alternate Names | |
| CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E, anti-CK6A, CK6B, CK6C, CK6D, CK6E, Keratin Type II Cytoskeletal 6A, Keratin Type II Cytoskeletal 6B, Keratin Type II Cytoskeletal 6C, Keratin Type II Cytoskeletal 6D, Keratin Type II Cytoskeletal 6E, KRT6, KRT6A, KRT6B, KRT6C, KRT6D, KRT6E antibody | |
| Molecular Weight | |
| 56kDa | |
| Chromosomal Location | |
| 12q13.13 ;12q13.13 ;12q13.13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KRT6A ;KRT6B ;KRT6C |
| Entrez Gene ID | 3853, 3854, 286887 |
| Ensemble Gene ID | ENSG00000205420, ENSG00000185479, ENSG00000170465 |
| RefSeq Protein Accession(s) | NP_005545, NP_005546, NP_775109 |
| RefSeq mRNA Accession(s) | NM_005554, NM_005555, NM_173086, |
| RefSeq Genomic Accession(s) | NG_008298, NC_000012, NC_018923, NG_008299, NC_018923, NC_000012, NC_000012, NC_018923, NG_012416 |
| UniProt ID(s) | P02538, A0A0S2Z428, P04259, P48668 |
| UniGene ID(s) | P02538, A0A0S2Z428, P04259, P48668 |
| HGNC ID(s) | 6443, 6444, 20406 |
| Cosmic ID(s) | KRT6A, KRT6B, KRT6C |
| KEGG Gene ID(s) | hsa:3853, hsa:3854, hsa:286887 |
| PharmGKB ID(s) | PA30231, PA30232, PA134891227 |
| General Description of Cytokeratin 6. | |
| This MAb recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. | |
Limitations and Warranty
enQuire Bio’s Cytokeratin 6 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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