PDF DatasheetHuman Anti-Desmin Antibody Product Attributes
Desmin Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-DES antibody staining is expected to be primarily localized to the intermediate filaments.
Observed Antibody Staining Data By Tissue Type:
Variations in Desmin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in myocytes in heart muscle and skeletal muscle and smooth muscle cells in the smooth muscle. More moderate antibody staining intensity was present in myocytes in heart muscle and skeletal muscle and smooth muscle cells in the smooth muscle. Low, but measureable presence of Desmin could be seen in. We were unable to detect Desmin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| Desmin General Information | |
|---|---|
| Alternate Names | |
| Desmin, DES | |
| Molecular Weight | |
| 52kDa | |
| Chromosomal Location | |
| 2q35 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DES |
| Entrez Gene ID | 1674 |
| Ensemble Gene ID | ENSG00000175084 |
| RefSeq Protein Accession(s) | NP_001918 |
| RefSeq mRNA Accession(s) | NM_001927 |
| RefSeq Genomic Accession(s) | NC_000002, NC_018913, NG_008043 |
| UniProt ID(s) | P17661, Q53SB5 |
| UniGene ID(s) | P17661, Q53SB5 |
| HGNC ID(s) | 2770 |
| Cosmic ID(s) | DES |
| KEGG Gene ID(s) | hsa:1674 |
| PharmGKB ID(s) | PA27253 |
| General Description of Desmin. | |
| Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain ?-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. | |
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