.jpg "Desmoglein-1 IHC human Skin (DSG1 1733)")
PDF DatasheetHuman Anti-Desmoglein-1 Antibody Product Attributes
Desmoglein-1 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Desmoglein-1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in epidermal cells in the skin, keratinocytes in skin, Langerhans in skin, squamous epithelial cells in the cervix, uterine, oral mucosa and vagina and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in epidermal cells in the skin, keratinocytes in skin, Langerhans in skin, squamous epithelial cells in the cervix, uterine, oral mucosa and vagina and urothelial cells in the urinary bladder. Low, but measureable presence of Desmoglein-1 could be seen in cells in the tubules in kidney, endothelial cells in the colon, glandular cells in the adrenal gland, breast, cervix, uterine, colon, endometrium, gallbladder, rectum, seminal vesicle and thyroid gland, hepatocytes in liver, melanocytes in skin, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the tonsil and trophoblastic cells in the placenta. We were unable to detect Desmoglein-1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Desmoglein-1 expression as measured by anti-Desmoglein-1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | ++ | – | – | – | – | – | – | – | + | – | + | – | + | – | – | + | – |
| DSG1 Variability | + | ++ | + | ++ | + | + | ++ | ++ | ++ | + | + | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ |
| Desmoglein-1 General Information | |
|---|---|
| Alternate Names | |
| Desmoglein-1, DSG1 | |
| Molecular Weight | |
| 150kDa (precursor) ;160kDa (mature) | |
| Chromosomal Location | |
| 18q12.1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DSG1 |
| Entrez Gene ID | 1828 |
| Ensemble Gene ID | ENSG00000134760 |
| RefSeq Protein Accession(s) | NP_001933 |
| RefSeq mRNA Accession(s) | NM_001942 |
| RefSeq Genomic Accession(s) | NC_000018, NG_011803, NC_018929 |
| UniProt ID(s) | Q02413 |
| UniGene ID(s) | Q02413 |
| HGNC ID(s) | 3048 |
| Cosmic ID(s) | DSG1 |
| KEGG Gene ID(s) | hsa:1828 |
| PharmGKB ID(s) | PA27501 |
| General Description of Desmoglein-1. | |
| Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. | |
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