PDF DatasheetHuman Anti-endoglin / CD105 Antibody Product Attributes
Species: Human
Tested Applications: Western Blot.
Clonality: Monoclonal
Anti-endoglin / CD105 Antibody Clone: ENG/1327
Clone ENG/1327 Host and Isotype: Mouse IgG1
Anti-Human endoglin / CD105 Positive Control Sample: HeLa, A431 and HL-60 cells. Colon.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human endoglin protein fragment (aa74-251)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
endoglin / CD105 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in endoglin / CD105 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney. More moderate antibody staining intensity was present in cells in the glomeruli in kidney. Low, but measureable presence of endoglin / CD105 could be seen in. We were unable to detect endoglin / CD105 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| endoglin / CD105 General Information | |
|---|---|
| Alternate Names | |
| endoglin, ENG, CD105, Cluster of Differentiation 105, S-endoglin | |
| Molecular Weight | |
| 84kDa | |
| Chromosomal Location | |
| 9q34.11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ENG |
| Entrez Gene ID | 2022 |
| Ensemble Gene ID | ENSG00000106991 |
| RefSeq Protein Accession(s) | NP_000109, NP_001108225, NP_001265067 |
| RefSeq mRNA Accession(s) | NM_001114753, NM_001278138, NM_000118, |
| RefSeq Genomic Accession(s) | NC_018920, NG_009551, NC_000009 |
| UniProt ID(s) | Q96CG0, B7Z6Y5, Q5T9B9, F5GX88, A0A024R878, P17813 |
| UniGene ID(s) | Q96CG0, B7Z6Y5, Q5T9B9, F5GX88, A0A024R878, P17813 |
| HGNC ID(s) | 3349 |
| Cosmic ID(s) | ENG |
| KEGG Gene ID(s) | hsa:2022 |
| PharmGKB ID(s) | PA27785 |
| General Description of endoglin / CD105. | |
| CD105/endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain. | |
Limitations and Warranty
enQuire Bio’s endoglin / CD105 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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