Antibody (Suitable for clinical applications)
Specification | Recommendation |
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Recommended Dilution (Conc) | 1:50-1:100 |
Pretreatment | Citrate Buffer pH 6.0 |
Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Ezrin/p81/Cytovillin Information for Pathologists
Summary:
Ezrin serves as a linker between the plasma membrane and cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin is also know as cytovillin or villin-2.
Ezrin/p81/Cytovillin General Information | |
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Alternate Names | |
Molecular Weight | |
69.4 kDa | |
Chromosomal Location | |
q25.3 [chr: 6] [chr_start: 158765741] [chr_end: 158819368] [strand: -1] | |
Curated Database and Bioinformatic Data | |
Gene Symbol | EZR |
Entrez Gene ID | 7430 |
RefSeq Protein Accession(s) | NP_001104547; NP_003370 |
RefSeq mRNA Accession(s) | NM_003379; XM_011536110; NM_001111077 |
RefSeq Genomic Accession(s) | NG_052952; NC_000006 |
UniProt ID(s) | P15311 |
PharmGKB ID(s) | PA162385512 |
KEGG Gene ID(s) | hsa:7430 |
General Description of Ezrin/p81/Cytovillin . | |
This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas. |
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