PDF DatasheetHuman Anti-FABP3 / H-FABP Antibody Product Attributes
FABP3 / H-FABP Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-FABP3 antibody staining is expected to be primarily localized to the golgi apparatus.
Observed Antibody Staining Data By Tissue Type:
Variations in FABP3 / H-FABP antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of FABP3 / H-FABP could be seen inmyocytes in skeletal muscle. We were unable to detect FABP3 / H-FABP in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| FABP3 / H-FABP General Information | |
|---|---|
| Alternate Names | |
| FABP3, H-FABP, Mdgi, H-FABP, Fabph-4, Fabph1, Fabph-1, Fabph4, Fatty Acid Binding Protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FABP3 |
| Entrez Gene ID | 2170 |
| Ensemble Gene ID | ENSG00000121769 |
| RefSeq Protein Accession(s) | NP_001307925, XP_011539309, NP_004093 |
| RefSeq mRNA Accession(s) | XM_011541007, NM_001320996, NM_004102, |
| RefSeq Genomic Accession(s) | NG_047049, NC_000001, NC_018912 |
| UniProt ID(s) | P05413 |
| UniGene ID(s) | P05413 |
| HGNC ID(s) | 3557 |
| Cosmic ID(s) | FABP3 |
| KEGG Gene ID(s) | hsa:2170 |
| PharmGKB ID(s) | PA27958 |
| General Description of FABP3 / H-FABP. | |
| Heart-type Fatty Acid-Binding Protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode. Like the other nine FABPs, H-FABP is involved in active fatty acid metabolism where it transports fatty acids from cell membrane to mitochondria for oxidation.
H-FABP is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of the pain. H-FABP is 20 times more specific to cardiac muscle than myoglobin. It is found at 10-fold lower levels in skeletal muscle than heart muscle and the amounts in the kidney, liver, and small intestine are even lower. H-FABP is recommended to be measured iwth troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest pain. H-FABP measured with troponin shows increased sensitivity of approximately 20% over troponin alone at 3-6 hours following the onset of chest pain. H-FABP also has prognostic value. Alongside D-dimer NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically significant predictor of death or recurrent MI at one year. This prognostic information was independent of other markers. |
|
There are no reviews yet.