.jpg "Factor XIIIa IHC human Placenta (SPM180)")
PDF DatasheetHuman Anti-Factor XIIIa Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-Factor XIIIa Antibody Clone: SPM180
Clone SPM180 Host and Isotype: Mouse IgG2b kappa
Anti-Human Factor XIIIa Positive Control Sample: 293T Cells. Placenta.
Cellular Localization of Antibody Cytoplasmic and Secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant fragment of human Factor XIIIa protein (aa46-181)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
Factor XIIIa Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in Factor XIIIa antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in fibroblasts in mesenchymal tissue. More moderate antibody staining intensity was present in fibroblasts in mesenchymal tissue. Low, but measureable presence of Factor XIIIa could be seen inadipocytes in mesenchymal tissue and Leydig cells in the testis. We were unable to detect Factor XIIIa in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| Factor XIIIa General Information | |
|---|---|
| Alternate Names | |
| Coagulation factor XIII A chain, F13A1 | |
| Molecular Weight | |
| 83kDa | |
| Chromosomal Location | |
| 6p25.3-p24.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | F13A1 |
| Entrez Gene ID | 2162 |
| Ensemble Gene ID | ENSG00000124491 |
| RefSeq Protein Accession(s) | NP_000120 |
| RefSeq mRNA Accession(s) | NM_000129 |
| RefSeq Genomic Accession(s) | NC_018917, NC_000006, NG_008107 |
| UniProt ID(s) | P00488 |
| UniGene ID(s) | P00488 |
| HGNC ID(s) | 3531 |
| Cosmic ID(s) | F13A1 |
| KEGG Gene ID(s) | hsa:2162 |
| PharmGKB ID(s) | PA162 |
| General Description of Factor XIIIa. | |
| This MAb recognizes a protein of 83kDa, which is identified as Factor XIIIa. It has been identified in platelets, megakaryocytes, and fibroblast-like mesenchymal or histiocytic cells in the placenta, uterus, and prostate, monocytes and macrophages and dermal dendritic cells. Anti-factor XIIIa has been found to be useful in differentiating between dermatofibroma (almost all cases are positive), dermatofibrosarcoma protuberans (-/+) and desmoplastic malignant melanoma (-). Anti-factor XIIIa positivity is also seen in capillary hemagioblastoma, hemangioendothelioma, hemangiopericytoma, xanthogranuloma, xanthoma, hepatocellular carcinoma, glomus tumor, and meningioma. | |
Limitations and Warranty
enQuire Bio’s Factor XIIIa Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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