Human Anti-Ferritin, Light Chain Antibody Product Attributes
Ferritin, Light Chain Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-FTL antibody staining is expected to be primarily localized to the cytosol.
Observed Antibody Staining Data By Tissue Type:
Variations in Ferritin, Light Chain antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the tubules in kidney, glial cells in the caudate nucleus and cerebral cortex, hepatocytes in liver, Leydig cells in the testis, macrophages in lung, neuronal cells in the caudate nucleus and Purkinje cells in the cerebellum. More moderate antibody staining intensity was present in cells in the tubules in kidney, glial cells in the caudate nucleus and cerebral cortex, hepatocytes in liver, Leydig cells in the testis, macrophages in lung, neuronal cells in the caudate nucleus and Purkinje cells in the cerebellum. Low, but measureable presence of Ferritin, Light Chain could be seen in cells in the endometrial stroma in endometrium, cells in the seminiferous ducts in testis, exocrine glandular cells in the pancreas, fibroblasts in skin and mesenchymal tissue, glandular cells in the breast, endometrium, epididymis, prostate, salivary gland, stomach and thyroid gland, Langerhans in skin, myocytes in heart muscle, neuronal cells in the cerebral cortex and hippocampus, respiratory epithelial cells in the nasopharynx, smooth muscle cells in the smooth muscle, squamous epithelial cells in the cervix, uterine, oral mucosa and tonsil, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. We were unable to detect Ferritin, Light Chain in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Ferritin, Light Chain expression as measured by anti-Ferritin, Light Chain antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal Intensity | – | – | – | – | + | ++ | + | ++ | ++ | – | ++ | – | – | ++ | ++ | + | – | – | ++ | ++ |
FTL Variability | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | +++ |
Ferritin, Light Chain General Information | |
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Alternate Names | |
FTL, Ferritin Light Chain | |
Molecular Weight | |
19-25kDa | |
Chromosomal Location | |
19q13.33 | |
Curated Database and Bioinformatic Data | |
Gene Symbol | FTL |
Entrez Gene ID | 2512 |
Ensemble Gene ID | ENSG00000087086 |
RefSeq Protein Accession(s) | NP_000137 |
RefSeq mRNA Accession(s) | NM_000146 |
RefSeq Genomic Accession(s) | NC_000019, NC_018930, NG_008152 |
UniProt ID(s) | P02792 |
UniGene ID(s) | P02792 |
HGNC ID(s) | 3999 |
Cosmic ID(s) | FTL |
KEGG Gene ID(s) | hsa:2512 |
PharmGKB ID(s) | PA28412 |
General Description of Ferritin, Light Chain. | |
Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. |
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