PDF DatasheetHuman Anti-FSH-beta Antibody Product Attributes
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml, 30 min RT)
Clonality: Monoclonal
Anti-FSH-beta Antibody Clone: SPM107
Clone SPM107 Host and Isotype: Mouse IgG1 kappa
Anti-Human FSH-beta Positive Control Sample: Anterior Pituitary
Cellular Localization of Antibody Cytoplasmic, secreted
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Full length purified Human FSH
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
FSH-beta Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in FSH-beta antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the anterior in pituitary gland. More moderate antibody staining intensity was present in cells in the anterior in pituitary gland. Low, but measureable presence of FSH-beta could be seen in. We were unable to detect FSH-beta in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| FSH-beta General Information | |
|---|---|
| Alternate Names | |
| Follitropin subunit beta, follicle-stimulating hormone beta subunit, FSH-B, FSHB | |
| Molecular Weight | |
| 22kDa | |
| Chromosomal Location | |
| 11p13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FSHB |
| Entrez Gene ID | 2488 |
| Ensemble Gene ID | ENSG00000131808 |
| RefSeq Protein Accession(s) | NP_000501, NP_001018090 |
| RefSeq mRNA Accession(s) | NM_001018080 NM_000510 |
| RefSeq Genomic Accession(s) | NC_018922, NG_008144, NC_000011 |
| UniProt ID(s) | P01225, A0A0F7RQE8 |
| UniGene ID(s) | P01225, A0A0F7RQE8 |
| HGNC ID(s) | 3964 |
| Cosmic ID(s) | FSHB |
| KEGG Gene ID(s) | hsa:2488 |
| PharmGKB ID(s) | PA28382 |
| General Description of FSH-beta. | |
| This MAb reacts with a protein of 22kDa, identified as beta sub-unit of FSH. It does not cross react with the alpha sub-unit. Follicle stimulating hormone (FSH) is a hormone synthesized, secreted by gonadotrophs in the anterior pituitary gland. In the ovary, FSH stimulates the growth of immature Graafian follicles to maturation. As the follicle grows, it releases inhibin, which deactivates the FSH production. In men, FSH enhances the production of,rogen-binding protein by the Sertoli cells of the testis, is critical for spermatogenesis. FSH, LH act synergistically in reproduction. FSH is a useful marker in the classification of pituitary tumors, the study of pituitary disease. | |
Limitations and Warranty
enQuire Bio’s FSH-beta Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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