PDF DatasheetHuman Anti-FSH-Receptor Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-FSH-Receptor Antibody Clone: FSHR/1400
Clone FSHR/1400 Host and Isotype: Mouse IgG1
Anti-Human FSH-Receptor Positive Control Sample: Uterine Carcinoma
Cellular Localization of Antibody Cytoplasmic ;Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length FSHR protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
FSH-Receptor Previously Observed Antibody Staining Patterns
| FSH-Receptor General Information | |
|---|---|
| Alternate Names | |
| Follicle-stimulating hormone receptor, FSH receptor, FSHR, | |
| Molecular Weight | |
| 75kDa | |
| Chromosomal Location | |
| 2p21-p16 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FSHR |
| Entrez Gene ID | 2492 |
| Ensemble Gene ID | ENSG00000170820 |
| RefSeq Protein Accession(s) | XP_011531037, NP_000136, XP_011531038, NP_852111, XP_011531036, XP_011531042, XP_011531035 |
| RefSeq mRNA Accession(s) | XM_011532736 NM_181446, XM_011532734, NM_000145, XM_011532733, XM_011532735, XM_011532740 |
| RefSeq Genomic Accession(s) | NG_008146, NC_018913, NC_000002 |
| UniProt ID(s) | A0A1D5RMN4, P23945 |
| UniGene ID(s) | A0A1D5RMN4, P23945 |
| HGNC ID(s) | 3969 |
| Cosmic ID(s) | FSHR |
| KEGG Gene ID(s) | hsa:2492 |
| PharmGKB ID(s) | PA28386 |
| General Description of FSH-Receptor. | |
| Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its ? and ? subunits. While the ? subunit of FSH is involved in the binding of FSH to the receptor, the ? subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome ;a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells. | |
Limitations and Warranty
enQuire Bio’s FSH-Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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