PDF DatasheetHuman Anti-GnRH-Receptor / LH-RH Receptor Antibody Product Attributes
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (1-2ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (1-2ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-GnRH-Receptor / LH-RH Receptor Antibody Clone: GNRHR/768
Clone GNRHR/768 Host and Isotype: Mouse IgG1 kappa
Anti-Human GnRH-Receptor / LH-RH Receptor Positive Control Sample: T47D cells. Pituitary gland, ovarian or breast cancers.
Cellular Localization of Antibody Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human GNRHR protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
GnRH-Receptor / LH-RH Receptor Previously Observed Antibody Staining Patterns
| GnRH-Receptor / LH-RH Receptor General Information | |
|---|---|
| Alternate Names | |
| Gonadotropin-releasing hormone receptor, GNRHR, LHCGR, Luteinizing hormone / Choriogonadotropin receptor, Lutropin / Choriogonadotropin receptor, LCGR, Luteinizing Hormone Receptor (LHR) | |
| Molecular Weight | |
| 54-60kDa | |
| Chromosomal Location | |
| 4q21.2 (GNRHR) & 2p16.3 (LHCGR) (Human) | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GNRHR, LHCGR |
| Entrez Gene ID | 2798, 3973 |
| Ensemble Gene ID | ENSG00000109163, ENSG00000138039 |
| RefSeq Protein Accession(s) | NP_000397, NP_001012781, XP_006712078, XP_011531133, XP_016859579, XP_005264366, XP_011531136, XP_016859578, XP_011531130, NP_000224 |
| RefSeq mRNA Accession(s) | NM_000406 NM_001012763, XM_011532828, XM_011532831, XM_017004090, XM_011532834, XM_006712015, XM_017004089, NM_000233 |
| RefSeq Genomic Accession(s) | NC_000004, NC_018915, NG_009293, NG_008193, NG_033050, NC_000002, NC_018913 |
| UniProt ID(s) | P30968, P22888 |
| UniGene ID(s) | P30968, P22888 |
| HGNC ID(s) | 4421, 6585 |
| Cosmic ID(s) | GNRHR, LHCGR |
| KEGG Gene ID(s) | hsa:2798, hsa:3973 |
| PharmGKB ID(s) | PA28800, PA30357 |
| General Description of GnRH-Receptor / LH-RH Receptor. | |
| Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis, ovulation by stimulating the testes, ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen, progesterone levels during the first trimester of pregnancy. Ovaries, testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular, intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy, Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal, granulosa cells as well as in ovarian cell membrane preparations. | |
Limitations and Warranty
enQuire Bio’s GnRH-Receptor / LH-RH Receptor Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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