PDF DatasheetHuman Anti-HLA-DP/-DQ/-DR Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-HLA-DP/-DQ/-DR Antibody Clone: CR3/43
Clone CR3/43 Host and Isotype: Mouse IgG1
Anti-Human HLA-DP/-DQ/-DR Positive Control Sample: Raji cells. Tonsil or lymph node
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Cells from human tonsil
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
HLA-DP/-DQ/-DR Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-HLA-DPB1 antibody staining is expected to be primarily localized to the cell junctions and nucleus.
| HLA-DP/-DQ/-DR General Information | |
|---|---|
| Alternate Names | |
| HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5,, anti-HLA-DPB1 antibody, anti-HLA-DQA1 antibody, anti-HLA-DQB1 antibody, anti-HLA-DRA antibody, anti-HLA-DRB1 antibody, anti-HLA-DRB3 antibody, anti-HLA-DRB4 antibody, anti-HLA-DRB5, antibody | |
| Molecular Weight | |
| 36kDa (? chain) and 27kDa (? chain) | |
| Chromosomal Location | |
| 6p21.3 (HLA-DP ;HLA-DR) | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HLA-DP ;HLA-DQ ;HLA-DR |
| Entrez Gene ID | 3115 |
| Ensemble Gene ID | ENSG00000226826, ENSG00000229295, ENSG00000230763, ENSG00000237710, ENSG00000230708, ENSG00000236693, ENSG00000215048, ENSG00000223865 |
| RefSeq Protein Accession(s) | NP_002112 |
| RefSeq mRNA Accession(s) | NM_002121 |
| RefSeq Genomic Accession(s) | NG_167245, NG_033242, NG_167247, NC_018917, NG_113891, NG_167246, NG_167249, NC_000006, NG_167244, NG_167248 |
| UniProt ID(s) | I4EC15, P04440 |
| UniGene ID(s) | I4EC15, P04440 |
| HGNC ID(s) | 4940 |
| Cosmic ID(s) | HLA-DPB1 |
| KEGG Gene ID(s) | hsa:3115 |
| PharmGKB ID(s) | PA35064 |
| General Description of HLA-DP/-DQ/-DR. | |
| Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP, -DQ and -DR. Human MHC class II antigens are transmembrane glycoproteins composed of an ? chain (36kDa) and a ? chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six ? and ten ? chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles. | |
Limitations and Warranty
enQuire Bio’s HLA-DP/-DQ/-DR Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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