PDF DatasheetHuman Anti-HLA-DP / HLA-DR Antibody Product Attributes
Species: Human
Tested Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (IHC).
Application Notes: Flow Cytometry (0.5-1ug of antibody/million cells in 0.1ml), Immunofluorescence (0.5-1ug of antibody/ml), Immunohistochemistry (IHC) (Formalin-fixed) (0.5-1ug of antibody/ml for 30 minutes at RT)
Clonality: Monoclonal
Anti-HLA-DP / HLA-DR Antibody Clone: Bra-14
Clone Bra-14 Host and Isotype: Mouse IgG3 kappa
Anti-Human HLA-DP / HLA-DR Positive Control Sample: Raji cells. Tonsil or lymph node
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Human REH cells
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
HLA-DP / HLA-DR Previously Observed Antibody Staining Patterns
| HLA-DP / HLA-DR General Information | |
|---|---|
| Alternate Names | |
| HLA-DP: HLA class II histocompatibility antigen DP alpha 1 chain, HLA DP1A, HLA SB alpha chain, HLADP, HLADPA1, HLASB, HLASB histocompatibility type, Human MHC class II HLA SB alpha, Major histocompatibility complex class II DP alpha 1, MHC class II DP3 alpha, MHC class II DPA1, PLT1, Primed lymphocyte test 1 HLA-DR: DR alpha chain, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR alpha chain, HLA DRA, HLA DRA1, HLA-DRA, HLADRA1, Major histocompatibility complex class II DR alpha, MHC cell surface glycoprotein, MHC class II antigen DRA, anti-HLA-DP: HLA class II histocompatibility antigen DP alpha 1 chain antibody, anti-HLA DP1A antibody, anti-HLA SB alpha chain antibody, anti-HLADP antibody, anti-HLADPA1 antibody, anti-HLASB antibody, anti-HLASB histocompatibility type antibody, anti-Human MHC class II HLA SB alpha antibody, anti-Major histocompatibility complex class II DP alpha 1 antibody, anti-MHC class II DP3 alpha antibody, anti-MHC class II DPA1 antibody, anti-PLT1 antibody, anti-Primed lymphocyte test 1 HLA-DR: DR alpha chain antibody, anti-HLA class II histocompatibility antigen antibody, anti-HLA class II histocompatibility antigen DR alpha chain antibody, anti-HLA DRA antibody, anti-HLA DRA1 antibody, anti-HLA-DRA antibody, anti-HLADRA1 antibody, anti-Major histocompatibility complex class II DR alpha antibody, anti-MHC cell surface glycoprotein antibody, anti-MHC class II antigen DRA antibody | |
| Molecular Weight | |
| 36kDa (? chain), 27kDa (? chain) | |
| Chromosomal Location | |
| 6p21.3 (HLA-DP & HLA-DR) | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HLA-DPB1 & HLA-DRA |
| Entrez Gene ID | 3115, 3122 |
| Ensemble Gene ID | ENSG00000226826, ENSG00000229295, ENSG00000230763, ENSG00000237710, ENSG00000230708, ENSG00000236693, ENSG00000215048, ENSG00000223865, ENSG00000227993, ENSG00000204287, ENSG00000277263, ENSG00000230726, ENSG00000234794, ENSG00000228987, ENSG00000226260, ENSG00000206308 |
| RefSeq Protein Accession(s) | NP_002112, NP_061984 |
| RefSeq mRNA Accession(s) | NM_002121, NM_019111 |
| RefSeq Genomic Accession(s) | NG_167245, NG_033242, NG_167247, NC_018917, NG_113891, NG_167246, NG_167249, NC_000006, NG_167244, NG_167248NC_000006, NG_187692, NG_167247, NG_113891, NC_018917, NG_167245, NG_167246, NG_167249, NG_002392, NG_167248 |
| UniProt ID(s) | I4EC15, P04440, P01903, A0A0G2JMH6 |
| UniGene ID(s) | I4EC15, P04440, P01903, A0A0G2JMH6 |
| HGNC ID(s) | 4940, 4947 |
| Cosmic ID(s) | HLA-DPB1, HLA-DRA |
| KEGG Gene ID(s) | hsa:3115, hsa:3122 |
| PharmGKB ID(s) | PA35064, PA35071 |
| General Description of HLA-DP / HLA-DR. | |
| Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR, DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36kDa), a chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages,, thymic epithelial cells, are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six , ten chain genes. Three loci, DR, DQ, DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles. | |
Limitations and Warranty
enQuire Bio’s HLA-DP / HLA-DR Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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