Anti-HLA-DR Antibody [L243]

Observed Antibody Staining Data By Tissue Type:

Variations in HLA-DR antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the glomeruli in kidney, germinal center cells in the lymph node and tonsil, glandular cells in the duodenum and endometrium, Langerhans in skin, lymphoid tissue in appendix, macrophages in lung, myoepithelial cells in the breast and non-germinal center cells in the lymph node and tonsil. More moderate antibody staining intensity was present in cells in the glomeruli in kidney, germinal center cells in the lymph node and tonsil, glandular cells in the duodenum and endometrium, Langerhans in skin, lymphoid tissue in appendix, macrophages in lung, myoepithelial cells in the breast and non-germinal center cells in the lymph node and tonsil. Low, but measureable presence of HLA-DR could be seen in cells in the red pulp in spleen, cells in the tubules in kidney, endothelial cells in the colon, epidermal cells in the skin, glandular cells in the appendix, cervix, uterine, epididymis and fallopian tube, glial cells in the caudate nucleus and hippocampus, myocytes in skeletal muscle, peripheral nerve in mesenchymal tissue, squamous epithelial cells in the tonsil and vagina and urothelial cells in the urinary bladder. We were unable to detect HLA-DR in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.