PDF DatasheetAntibody (Suitable for clinical applications)
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:25-1:50 |
| Pretreatment | Citrate Buffer pH 6.0 |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Inhibin Information for Pathologists
Summary:
Inhibin is a heterodimeric protein (with alpha and beta subunits) that inhibits or activates pituitary FSH secretion. Serum levels elevated (2x) in women with Down fetus. Positive staining – normal Sertoli cells (diffuse and strong), granulosa cells, prostate, brain, adrenal. Positive staining – disease
Common Uses By Pathologists:
Normal sertoli cells (diffuse and strong), granulosa cells, prostate, brain, and adrenal as well as Sex-cord stromal tumors, including Sertoli cell tumors, adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts (Am J Surg Pathol 2001;25:1200), and some carcinomas stain positive for Inhibin A. Primary ovarian carcinomas are usually negative for the protein.
| Inhibin General Information | |
|---|---|
| Alternate Names | |
| Curated Database and Bioinformatic Data | |
| UniProt ID(s) | Multiple |
| General Description of Inhibin . | |
| Inhibin is a dimeric glycoprotein hormone from the TGF-beta family made of alpha and beta subunits. This antibody recognizes the 32kDa alpha subunit of human inhibin. Inhibin alpha is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in fetoplacental unit. | |
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