PDF DatasheetHuman Anti-Lipoprotein-associated phospholipase A2 Antibody Product Attributes
Species: Human
Tested Applications: ?ELISA, CLIA, LFIA (Lateral Flow Immunoassay).
Clonality: Monoclonal
Anti-Lipoprotein-associated phospholipase A2 Antibody Clone: PLA2G7-Q10
Clone PLA2G7-Q10 Host and Isotype: Mouse IgG3
Buffer and Stabilizer: PBS (pH 7.4)
Antibody Purification Method:Protein G
Storage Conditions: Upon receipt aliquot and store at -20C or -80C. Avoid repeated freeze.
Lipoprotein-associated phospholipase A2 Previously Observed Antibody Staining Patterns
| Lipoprotein-associated phospholipase A2 General Information | |
|---|---|
| Alternate Names | |
| Phospholipase A2 Group VII, Group-VIIA Phospholipase A2, LDL-PLA, LDL-PLA2, LDL-PLA(2), PAFAD | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PLA2G7 |
| Entrez Gene ID | 7941 |
| Ensemble Gene ID | ENSG00000146070 |
| RefSeq Protein Accession(s) | XP_005249465, NP_001161829, NP_005075 |
| RefSeq mRNA Accession(s) | NM_001168357, XR_001743639 NM_005084, XM_005249408 |
| RefSeq Genomic Accession(s) | NC_000006, NC_018917, NG_016204 |
| UniProt ID(s) | Q13093 |
| UniGene ID(s) | Q13093 |
| HGNC ID(s) | 9040 |
| Cosmic ID(s) | PLA2G7 |
| KEGG Gene ID(s) | hsa:7941 |
| PharmGKB ID(s) | PA33368 |
| General Description of Lipoprotein-associated phospholipase A2. | |
| Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme in humans. Lp-PLA2 is a 45 kDa protein of 441 amino acids encoded by the gene. Some recent studies have shown that Lp-PLA2 is an independent risk marker for cardiovascular disease (CVD), including coronary heart disease (CHD), and ischemic stroke. In these studies, increased concentrations of Lp-PLA2 were seen in many people who were diagnosed with CHD and ischemic stroke, regardless of other risk factors. These findings make relatively the new test potentially useful among the growing number of cardiac risk markers used to determine a person’s risk of developing CVD. Lp-PLA2 is specific for vascular inflammation and is a circulating measure of the progression of rupture-prone plaque. Following production by inflammatory cells, this enzyme cleaves oxidized phospholipids, generating pro-inflammatory molecules and oxidized fatty acids. Elevated Lp-PLA2 levels can predict the development of coronary artery disease in apparently healthy individuals and the risk of future adverse cardiac and cerebrovascular events. The Lp-PLA2 tests are meaningful for assessing risk of coronary artery disease and stroke. | |
Limitations and Warranty
enQuire Bio’s Anti-Human Lipoprotein-associated phospholipase A2 Antibody is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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