PDF DatasheetAntibody (Suitable for clinical applications)
Sample Type: FFPE Patient Samples.
Tested Applications: IHC. Approved for In Vitro Diagnostic Procedures on FFPE tissues. For tissue collection recommendations, please see datasheet sent with product.
Application Notes
| Specification | Recommendation |
|---|---|
| Recommended Dilution (Conc) | 1:50-1:100 |
| Pretreatment | HistoZyme |
| Incubation Parameters | 30 min at Room Temperature |
Prior to use, inspect vial for the presence of any precipitate or other unusual physical properties. These can indicate that the antibody has degraded and is no longer suitable for patient samples. Please run positive and negative controls simultaneously with all patient samples to account and control for errors in laboratory procedure. Use of methods or materials not recommended by enQuire Bio including change to dilution range and detection system should be routinely validated by the user.
Clonality: Polyclonal
Anti-Lysozyme/Muramidase Antibody Clone: Polyclonal
Host and Isotype: Rabbit Undetermined
Recommended Positive Control Sample: Tonsil
Cellular Localization of Antibody Polyclonal Staining: Cytoplasmic
Buffer and Stabilizer: PBS with 1% BSA and 0.05% NaN3
Antibody Concentration: Lot specific. Plese contact tech support for data.
Immunogen: Lysozyme isolated from urine of patients with monocytic leukemia.
Storage Conditions: This antibody should be stored refrigerated (2-8°C). This product should not be used past the expiration date printed on the vial.
Lysozyme/Muramidase Information for Pathologists
Summary:
Also called muramidase. Histiocytic enzyme that cuts muramic acid linkages in walls of bacterial cells (Wikipedia: Lysozyme [Accessed 3 August 2018]). Microscopic (histologic) images Images hosted on PathOut server:.
| Lysozyme/Muramidase General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 16.5 kDa | |
| Chromosomal Location | |
| q15 [chr: 12] [chr_start: 69348341] [chr_end: 69354234] [strand: 1] | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LYZ |
| Entrez Gene ID | 4069 |
| RefSeq Protein Accession(s) | NP_000230 |
| RefSeq mRNA Accession(s) | NM_000239; |
| RefSeq Genomic Accession(s) | NG_008195; NC_000012 |
| UniProt ID(s) | P61626 |
| PharmGKB ID(s) | PA30503 |
| KEGG Gene ID(s) | hsa:4069 |
| Associated Diseases (KEGG IDs) | Amyloidosis 8 (AMYL8) [MIM:105200]: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. {ECO:0000269|PubMed:8464497}. The disease is caused by mutations affecting the gene represented in this entry. |
| General Description of Lysozyme/Muramidase . | |
| This antibody reacts with lysozyme. It stains granulocytes, monocytes and macrophages in human tonsil, skin and colon. This antibody does not cross-react with any other cell types. | |
Limitations and Warranty
This antibody is manufactured in accordance with clinical good manufacturing practices in an ISO13485:2016 certified production facility. It is intended for multiple uses including in vitro diagnostic use and research use only applications. Please see vial label for expiration date. We strive to always deliver antibodies with a shelf life of at least two years.
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