Human Anti-MALT1 Antibody Product Attributes
MALT1 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-MALT1 antibody staining is expected to be primarily localized to the cytosol and nucleoli.
Observed Antibody Staining Data By Tissue Type:
Variations in MALT1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in germinal center cells in the lymph node, tonsil. More moderate antibody staining intensity was present in germinal center cells in the lymph node, tonsil. Low, but measureable presence of MALT1 could be seen indecidual cells in the placenta, glandular cells in the colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate and stomach, lymphoid tissue in appendix, macrophages in lung, respiratory epithelial cells in the nasopharynx, squamous epithelial cells in the esophagus and urothelial cells in the urinary bladder. We were unable to detect MALT1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MALT1 expression as measured by anti-MALT1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal Intensity | – | – | – | – | – | – | + | – | – | + | – | – | – | + | – | + | – | – | – | – |
MALT1 Variability | ++ | + | ++ | ++ | ++ | + | ++ | ++ | ++ | ++ | + | + | + | ++ | + | ++ | + | + | + | ++ |
MALT1 General Information | |
---|---|
Alternate Names | |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1, MALT1 | |
Molecular Weight | |
93kDa | |
Chromosomal Location | |
18q21.32 | |
Curated Database and Bioinformatic Data | |
Gene Symbol | MALT1 |
Entrez Gene ID | 10892 |
Ensemble Gene ID | ENSG00000172175 |
RefSeq Protein Accession(s) | XP_011524096, NP_006776, NP_776216 |
RefSeq mRNA Accession(s) | XR_001753135 NM_006785, XM_011525794, NM_173844, XR_001753134, XR_001753136 |
RefSeq Genomic Accession(s) | NC_018929, NG_033893, NC_000018 |
UniProt ID(s) | Q9UDY8, A8K5S1 |
UniGene ID(s) | Q9UDY8, A8K5S1 |
HGNC ID(s) | 6819 |
Cosmic ID(s) | MALT1 |
KEGG Gene ID(s) | hsa:10892 |
PharmGKB ID(s) | PA30568 |
General Description of MALT1. | |
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains, fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21,, the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas, apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung, kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization, activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells, plasma cells. |
There are no reviews yet.