Anti-MCM7 Antibody Clone MCM7/1468

Observed Subcellular, Organelle Specific Staining Data:

Variations in MCM7 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the seminiferous ducts in testis, epidermal cells in the skin, germinal center cells in the lymph node and tonsil, glandular cells in the appendix, colon, duodenum, rectum and stomach, hematopoietic cells in the bone marrow, non-germinal center cells in the lymph node, squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in cells in the seminiferous ducts in testis, epidermal cells in the skin, germinal center cells in the lymph node and tonsil, glandular cells in the appendix, colon, duodenum, rectum and stomach, hematopoietic cells in the bone marrow, non-germinal center cells in the lymph node, squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina and trophoblastic cells in the placenta. Low, but measureable presence of MCM7 could be seen infollicle cells in the ovary, glandular cells in the adrenal gland, endometrium, fallopian tube, parathyroid gland and salivary gland, Leydig cells in the testis, ovarian stroma cells in the ovary, respiratory epithelial cells in the bronchus and urothelial cells in the urinary bladder. We were unable to detect MCM7 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.