Anti-MCM7 / CDC47 Antibody Clone SPM379

$ 199.00$ 459.00

SKU: 4176-MSM5X
Species: Human
Tested Applications: Immunohistochemistry (IHC)
Available Conjugates: Unconjugated
Isotype: Mouse IgG1 kappa
Mass Spec Validated?: Not MS Validated

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Human Anti-MCM7 / CDC47 Antibody Product Attributes

Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-MCM7 / CDC47 Antibody Clone: SPM379
Clone SPM379 Host and Isotype: Mouse IgG1 kappa
Anti-Human MCM7 / CDC47 Positive Control Sample: Exponentially growing any cultured human cells. Tonsil or lymph node.
Cellular Localization of Antibody Nuclear
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length hCDC47 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.

MCM7 / CDC47 Previously Observed Antibody Staining Patterns

Observed Subcellular, Organelle Specific Staining Data:

Anti-MCM7 antibody staining is expected to be primarily localized to the nucleoplasm.

Observed Antibody Staining Data By Tissue Type:

Variations in MCM7 / CDC47 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the seminiferous ducts in testis, epidermal cells in the skin, germinal center cells in the lymph node and tonsil, glandular cells in the appendix, colon, duodenum, rectum and stomach, hematopoietic cells in the bone marrow, non-germinal center cells in the lymph node, squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in cells in the seminiferous ducts in testis, epidermal cells in the skin, germinal center cells in the lymph node and tonsil, glandular cells in the appendix, colon, duodenum, rectum and stomach, hematopoietic cells in the bone marrow, non-germinal center cells in the lymph node, squamous epithelial cells in the esophagus, oral mucosa, tonsil and vagina and trophoblastic cells in the placenta. Low, but measureable presence of MCM7 / CDC47 could be seen infollicle cells in the ovary, glandular cells in the adrenal gland, endometrium, fallopian tube, parathyroid gland and salivary gland, Leydig cells in the testis, ovarian stroma cells in the ovary, respiratory epithelial cells in the bronchus and urothelial cells in the urinary bladder. We were unable to detect MCM7 / CDC47 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.

Observed Antibody Staining Data By Tissue Disease Status:

Tissues from cancer patients, for instance, have their own distinct pattern of MCM7 / CDC47 expression as measured by anti-MCM7 / CDC47 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.

Sample Type breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testicular cancer thyroid cancer urothelial cancer
Signal Intensity +++ ++ +++ +++ ++ ++ ++ + ++ +++ +++ +++ +++ + + +++ ++ +++ ++ ++
MCM7 Variability ++ +++ + ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + ++ +++

Limitations and Warranty

enQuire Bio’s MCM7 / CDC47 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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Anti-MCM7 / CDC47 Antibody Clone SPM379

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