Human Anti-MMP2 / Collagenase Type IV A Antibody Product Attributes
MMP2 / Collagenase Type IV A Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in MMP2 / Collagenase Type IV A antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in endothelial cells in the cerebral cortex and colon and trophoblastic cells in the placenta. More moderate antibody staining intensity was present in endothelial cells in the cerebral cortex and colon and trophoblastic cells in the placenta. Low, but measureable presence of MMP2 / Collagenase Type IV A could be seen in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the red pulp in spleen, glandular cells in the cervix, uterine, fallopian tube, parathyroid gland and prostate, Leydig cells in the testis, myocytes in heart muscle and smooth muscle cells in the smooth muscle. We were unable to detect MMP2 / Collagenase Type IV A in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MMP2 / Collagenase Type IV A expression as measured by anti-MMP2 / Collagenase Type IV A antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal Intensity | – | – | – | – | – | – | – | – | – | – | – | – | + | – | – | – | + | – | – | – |
MMP2 Variability | + | + | + | + | + | + | ++ | ++ | ++ | + | + | ++ | ++ | ++ | ++ | + | ++ | + | ++ | ++ |
MMP2 / Collagenase Type IV A General Information | |
---|---|
Alternate Names | |
matrix metalloproteinase-2, MMP-2, gelatinase, MMP2 | |
Molecular Weight | |
72kDa (Pro) ;63kDa (cleaved) | |
Chromosomal Location | |
16q12.2 | |
Curated Database and Bioinformatic Data | |
Gene Symbol | MMP2 |
Entrez Gene ID | 4313 |
Ensemble Gene ID | ENSG00000087245 |
RefSeq Protein Accession(s) | NP_004521, NP_001121363, NP_001289439, NP_001289437, NP_001289438 |
RefSeq mRNA Accession(s) | NM_001302510, NM_004530, NM_001127891, NM_001302508, NM_001302509, |
RefSeq Genomic Accession(s) | NG_008989, NC_000016, NC_018927 |
UniProt ID(s) | P08253, A0A024R6R4 |
UniGene ID(s) | P08253, A0A024R6R4 |
HGNC ID(s) | 7166 |
Cosmic ID(s) | MMP2 |
KEGG Gene ID(s) | hsa:4313 |
PharmGKB ID(s) | PA30877 |
General Description of MMP2 / Collagenase Type IV A. | |
This MAb recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV,V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway. |
There are no reviews yet.