PDF DatasheetHuman Anti-MRP1 / ABCC1 Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-MRP1 / ABCC1 Antibody Clone: MRP1/1343
Clone MRP1/1343 Host and Isotype: Mouse IgG1
Anti-Human MRP1 / ABCC1 Positive Control Sample: A549 cells. Colon, Endometrium, Ovary. Testis or Tonsil.
Cellular Localization of Antibody Cytoplasmic and Cell Surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human full-length ABCC1
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
MRP1 / ABCC1 Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-abcc1 antibody staining is expected to be primarily localized to the plasma membrane.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of MRP1 / ABCC1 expression as measured by anti-MRP1 / ABCC1 antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
| Sample Type | breast cancer | carcinoid | cervical cancer | colorectal cancer | endometrial cancer | glioma | head and neck cancer | liver cancer | lung cancer | lymphoma | melanoma | ovarian cancer | pancreatic cancer | prostate cancer | renal cancer | skin cancer | stomach cancer | testicular cancer | thyroid cancer | urothelial cancer |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal Intensity | – | – | – | – | + | – | – | – | – | – | + | – | – | – | – | – | – | – | + | – |
| ABCC1 Variability | + | ++ | + | + | ++ | ++ | ++ | + | + | ++ | ++ | + | + | + | ++ | + | + | + | ++ | + |
| MRP1 / ABCC1 General Information | |
|---|---|
| Alternate Names | |
| Multidrug resistance-associated protein 1, MRP1, ABCC1 | |
| Molecular Weight | |
| 190kDa | |
| Chromosomal Location | |
| 16p13.11 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ABCC1 |
| Entrez Gene ID | 4363 |
| Ensemble Gene ID | ENSG00000103222, ENSG00000278183 |
| RefSeq Protein Accession(s) | XP_011520800, XP_016878728, NP_004987, XP_016878729, XP_011520799, XP_016878726, XP_016878730, XP_016878732, XP_016878727, XP_016878731 |
| RefSeq mRNA Accession(s) | XM_017023240, NM_019901, XM_017023242, NM_019862, XM_011522497, XM_017023241, NM_004996 NM_019900, XM_017023237, NM_019902, XM_011522498, XM_017023243, NM_019899, XM_017023238, XM_017023239, NM_019898 |
| RefSeq Genomic Accession(s) | NG_187607, NC_018927, NG_028268, NC_000016 |
| UniProt ID(s) | P33527 |
| UniGene ID(s) | P33527 |
| HGNC ID(s) | 51 |
| Cosmic ID(s) | ABCC1 |
| KEGG Gene ID(s) | hsa:4363 |
| PharmGKB ID(s) | PA244 |
| General Description of MRP1 / ABCC1. | |
| The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. | |
Limitations and Warranty
enQuire Bio’s MRP1 / ABCC1 Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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